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Table 2 Compliance (mean hours/night) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study

PMID

Baseline AHI (SD)

[Eligibility]

Baseline ESS (SD)

Duration (design)

Interventions

Number analyzed

Final

Change

(final)

Net difference

or difference

P

Dropout (%)

Study quality

d'Ortho 2000 [32]

11035671

58 (6)

[≥10]

12.7 (5.3)

2 months

(XO)

APAP

25

4.1

-0.6

-1.5, 0.32a

0.20

0

B

    

CPAP

25

4.7

     

Damjanovic 2009 [10]

19129293

44 (25)

[≥15]

8.8 (5.2)

3 months

(PL)

APAP

46

5.4

0

-0.7, 0.7

nd

8

B

    

CPAP

46

5.4

     
   

9 months

(PL)

APAP

34

5.2

0.1

-0.9, 1.1

nd

22

 
    

CPAP

44

5.1

     

Fietze 2007 [11]

17337881

42 (26)

[≥10]

nd

1.5 months

(PL)

APAP

20

5.0

0.8

nd

NS

0

C

    

CPAP

21

4.2

     

Galetke 2008 [12]

17148931

33 (19)

[> 10]

10.3 (5.7)

2 months

(XO)

APAP

20

6.37

-0.01

-0.82, 0.8

nd

nd

C

    

CPAP

20

6.38

     

Hudgel 2000 [18]

10947032

30 (25)

[nd]

16.0 (5.0)

3 months

(XO)

APAP

14

6.0

0.5

0.02, 0.98a

< 0.04

35

C

    

CPAP

19

5.5

     

Hukins 2004 [19]

15683142

56 (nd)

12.5 (nd)

1 to 2 months

(XO)

APAP

46

5.05

0.19

-0.06, 0.44a

0.14

16

B

    

CPAP

46

4.86

     

Hussain 2004 [20]

15072173

47 (36)

[> 15]

11.1 (6.4)

1 month

(XO)

APAP

10

4.3

0.6

-0.84, 2.04

nd

0

C

    

CPAP

10

3.7

     

Konermann 1998 [31]

9515848

38 (14)

[> 20]

nd

3 to 6 months

(PL)

APAP

25

6.5

0.8

0.19, 1.41a

< 0.01

4

B

    

CPAP

23

5.7

     

Marrone 2004 [21]

15165530

68 (12)

[30]

16.3 (5.0)

1 month

(XO)

APAP

22

4.9

0.5

-0.26, 1.26

nd

0

C

    

CPAP

22

4.4

     

Massie 2003 [22]

12406840

nd

[≥15]

nd

1.5 months

(XO)

APAP

44

5.1

0.58

0.18, 0.99a

0.005

4

B

    

CPAP

44

4.52

     

Meurice 2007 [13]

17638595

55 (10)

[nd]

11.8 (4.9)

3 months

(PL)

APAP (AutoSet)

15

6.0

-0.1

-0.79, 0.59

nd

15

B

    

CPAP

14

6.1

     
   

6 months

(PL)

APAP (AutoSet)

15

6.1

-0.4

-1.28, 0.48

nd

15

 
    

CPAP

14

6.5

     

Nolan 2007 [14]

17326544

15 (8)

[≥5]

12.3 (4.0)

2 months

(XO)

APAP

29

4.9

0

nd

0.94

15

B

    

CPAP

29

4.9

     

Noseda 2004 [23]

15249439

51 (25) [> 20]

10.7 (2.4)

2 months

(XO)

APAP

24

5.3

-0.2

-0.89, 0.49

nd

11

B

    

CPAP

24

5.5

     

Nussbaumer 2006 [15]

16537862

41 (20)

[> 10]

12.7 (3.3)

1 month

(XO)

APAP

30

5.1

0.3

-0.29, 0.89

nd

12

B

    

CPAP

30

4.8

     

Patruno 2007 [16]

17494789

46 (14)

[> 20]

15 (2.7)

3 months

(PL)

APAP

15

6.2

0.2

-0.25, 0.65

nd

23

C

    

CPAP

16

6.0

     

Planes 2003 [29]

12683473

59 (17)

[≥30]

15.1 (3.9)

2 months

(PL)

APAP

16

4.5

-0.8

nd

NS

14

C

    

CPAP

14

5.3

     

Randerath 2001 [26]

11254519

35 (26)

[≥10]

11.1 (5.1)

1.5 months

(XO)

APAP

46

5.26

0

-0.44, 0.44

nd

12

B

    

CPAP

46

5.26

     

Resta 2004 [24]

15679008

47 (11)

[> 30]

13.9 (3.2)

1 month

(PL)

APAP

10

5.2

-0.1

-1.12, 0.92

nd

0

C

    

CPAP

10

5.3

     

Senn 2003 [25]

14525804

46 (23)

[> 10]

14.2 (3.8)

1 month

(XO)

APAP (Autoset T)

29

5.5

-0.1

nd

NS

7

B

    

APAP (AutoAdjust)

29

5.5

-0.1

nd

NS

  
    

CPAP

29

5.6

     

Sériès 1997 [27]

9341056

44 (20)

[nd]

15.5 (4.5)

0.75 months

(PL)

APAPb

12

ndc

-

-

NS

0

C

    

CPAP

12

nd

     
    

APAPd

12

ndc

-

-

NS

  
    

CPAP

12

nd

     

Vennelle 2010 [30]

20175411

33 (18) [≥15]

14 (3)

6 weeks (XO)

APAP

181

4.2

0.2

0.003, 0.397

0.047

9.5

A

    

CPAP

181

4.0

     

Teschler 2000 [28]

10885414

53 (26)

[> 20]

nd

2 months

(XO)

APAP

10

6.3

0.2

-0.7, 1.1

nd

nd

C

    

CPAP

10

6.1

     

To 2008 [17]

18197915

54 (nd)

[> 30]

13.4 (nd)

1 month

(XO)

APAP

41

4.3

0.5

0.02, 0.98

0.04

5

B

    

CPAP

41

3.8

     
   

2 months

(XO)

APAP

41

4.4

0.7

0.17, 1.23a

0.01

  
    

CPAP

41

3.7

     

West 2006 [33]

16254055

33e (nd)

[> 10]

16.5f (nd)

1 month

(PL)

APAP

29

5.3

  

0.27

6.1

A

    

CPAP (auto)

31

4.3

     
    

CPAP (algo)

32

4.7

     
   

6 months

(PL)

APAP

28

5.5

  

0.23

  
    

CPAP (auto)

31

4.9

     
    

CPAP (algo)

27

4.0

   

9.2

 
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported P value. bEstimated effective pressure. cDirections of changes not reported in the study. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm, median. fMedian in algorithm-determined CPAP arm.