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Table 5 Arousal index (events/hour) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study

PMID

Baseline AHI (SD)

[eligibility]

Baseline ESS (SD)

Duration (design)

Interventions

Number analyzed

Baseline (SD)

Change

(final)

Net difference

or difference

95% CIa

P

Dropout (%)

Study quality

d'Ortho 2000 [32]

11035671

58 (6)

[≥10]

12.7 (5.3)

2 months

(XO)

APAP

25

45.6

(25.8)

-30.1

1.8

nd

NS

0

B

    

CPAP

25

45.6

(25.8)

-31.9

     

Damjanovic 2009 [10]

19129293

44 (25)

[≥15]

8.8 (5.18)

3 months

(PL)

APAP

46

30.6 (22.4)

-18.3

-0.2

-7.92 to 7.52

nd

8

B

    

CPAP

46

34.5

(21.0)

-18.1

     
   

9 months

(PL)

APAP

34

30.6 (22.4)

-17.7

3.6

-4.09 to 11.29

nd

22

 
    

CPAP

44

34.5

(21.0)

-21.3

     

Galetke 2008 [12]

17148931

33 (19)

[> 10]

10.3 (5.7)

2 months

(XO)

APAP

20

17.6 (9.2)

-4.0

1.0

-2.52 to 4.52

nd

nd

C

    

CPAP

20

17.6 (9.2)

-5.0

     

Hussain 2004 [20]

15072173

47 (36)

[> 15]

11.1 (6.4)

1 month

(XO)

APAP

10

17.3 (17.7)

-11.4

1.0

-2.5 to 4.5

nd

0

C

    

CPAP

10

17.3 (17.7)

-12.4

     

Konermann 1998 [31]

9515848

38 (14)

[> 20}

nd

3 to 6 months

(PL)

APAP

25

16.9 (10.5)

-9.5

-3.3

-6.6 to 0b

< 0.05

4

B

    

CPAP

23

13.3

(13.3)

-6.2

     

Nolan 2007 [14]

17326544

15 (8)

[≥5)

12.3 (4)

2 months

(XO)

APAP

29

16.0 (14.0)

-14.0

-3.0

-5.7 to -0.29b

0.03

15

B

    

CPAP

29

16.0 (14.0)

-11.0

     

Planes 2003 [29]

12683473

59 (17)

[≥30]

15.1 (3.9)

2 months

(PL)

APAP

16

44.4 (19.1)

 

3.3

-7.14 to 12.74

nd

14

C

    

CPAP

14

48.5 (14.2)

      

Randerath 2001 [26]

11254519

35 (26)

[≥10]

11.1 (5.1)

1.5 months

(XO)

APAP

52

34 (21.7)

-23.1

-1.7

-3.7 to 0.3

nd

12

B

    

CPAP

52

34 (21.7)

-21.4

     

Resta 2004 [24]

15679008

47 (11)

[> 30]

13.9 (3.2)

1 month

(PL)

APAP

10

43.1 (11.9)

-35.7

0.1

-8.29 to 8.49

nd

0

C

    

CPAP

10

43.1 (9.1)

-35.8

     

Sériès 1997 [27]

9341056

44 (20)

[nd]

15.5 (4.5)

0.75 months

(PL)

APAPc

12

nd

nd

-

-

NS

0

C

    

CPAP

12

nd

nd

     
    

APAPd

12

nd

nd

-

-

NS

  
    

CPAP

12

nd

nd

     
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dMeasured effective pressure.