Table 1 Characteristics of the 22 identified surgical IPDMAs
From: A systematic review of individual patient data meta-analyses on surgical interventions
Author and year | RCTs ( n) | Patients ( n) | Patients | Intervention | Comparison | Outcome | Subgroups ( n) | Overall effect estimate | Significant effect estimates in subgroups ( n/ N) |
|---|---|---|---|---|---|---|---|---|---|
Jorgenson et al., 2007 [19] | 7 | 2,091 | Women with cervical insufficiency | Cervical cerclage | Expectant management, no cerclage | Primary | Obstetric history, cervical length (2) | NS | 0/2 |
Pregnancy loss or neonatal death before discharge from hospital | |||||||||
Secondary | |||||||||
Preterm delivery and maternal morbidity | |||||||||
Hlatky et al., 2009 [20] | 10 | 7,812 | Patients with multivessel coronary disease | Coronary artery bypass graft | Percutaneous coronary intervention | All-cause mortality | Age, sex, diabetes, smoking, hypertension, hypercholesterolaemia, PVD, stability of symptoms, previous MI, heart failure, LV function, no. of diseased vessel, proximal LAD, balloon vs. stent (14) | NS | 2/14 |
Daniels et al., 2010 [21] | 5 | 862 | Patients with chronic pelvic pain | Laparoscopic uterosacral nerve ablation (LUNA) | No LUNA | Derived measure of worst pain level experienced | Presence of visual pathology, site of pain, age, parity (4) | NS | 1/4 |
Burzotta et al., 2009 [22] | 11 | 2,686 | Patients with ST-elevation myocardial infarction (STEMI) | Percutaneous coronary intervention with thrombectomy | Standard percutaneous coronary intervention | Primary | Manual vs. non-manual thrombectomy devices, diabetes, primary vs. rescue PCI, treated vs. non-treated with IIb/IIIa-inhibitors, ischemic time, infarct-related artery, pre-PCI TIMI flow (7) | S | 1/7 |
All-cause mortality | |||||||||
Secondary | |||||||||
Survival free from MI, TLR, or TVR, major adverse coronary events (MACE), death+MI | |||||||||
Carotid Stenting Trialists’Collaboration, 2010 [23] | 3 | 3,433 | Patients with symptomatic carotid stenosis | Carotid stenting | Endarterectomy | Primary | Age, sex, diabetes, hypertension, SBP, hypercholesterolaemia, smoking, coronary heart disease, peripheral artery disease, most recent ipsilateral ischemic event, history of stroke, degree of ipsilateral ischemic stroke, contralateral severe carotid stenosis or occlusion, treatment within 14 days, patients recruited per center, center recruitment rate (16) | S | 1/16 |
Any stroke or death | |||||||||
Secondary | |||||||||
Disabling stroke or death, all-cause death, any stroke, myocardial infarction, severe local hematoma, severe wound infection | |||||||||
Middleton et al., 2010 [24] | 17 | 2,814 | Patients with heavy menstrual bleeding | Hysterectomy, endometrial destruction (1st & 2nd generation), levonorgestrel releasing intra-uterine system (MIRENA) | Endometrial destruction (1st & 2nd generation), levonorgestrel releasing intra-uterine system (MIRENA) | Dissatisfaction rates | Uterine cavity length, age, presence of fibroids/polyps, parity, baseline bleeding score (5) | S | 1/5 |
Mercado et al., 2005 [25] | 4 | 3,051 | Patients with multi-system coronary artery disease | Percutaneous coronary intervention with multiple stenting | Coronary artery bypass graft | Primary | Age, gender, diabetes, smoking, number of diseased vessels (5) | NS | 0/5 |
Composite of death, MI, or stroke at 1 year FU | |||||||||
Secondary | |||||||||
Death, composite of death or MI, repeat revascularization, composite of death, MI, stroke, and repeat revalscularization | |||||||||
Boersma et al., 2006 [26] | 22 | 6,767 | Patients with acute myocardial infarction | PCI | Fibrinolysis | All-cause mortality | Age, sex, diabetes, prior MI, MI location, heart rate, SBP, fibrinolytic agent, front-loaded tPA, site volume (11) | S | 1/11 |
Timmer et al., 2007 [27] | 19 | 6,315 | Patients with acute myocardial infarction | PCI | Fibrinolysis | Death, recurrent MI, death or recurrent MI, stroke | Diabetes (1) | S | 0/1 |
de Boer et al., 2010 [28] | 22 | 6,767 | Patients with acute myocardial infarction | Primary PCI | Fibrinolysis | Primary | Age (1) | S | 0/1 |
All-cause mortality | |||||||||
Secondary reMI, stroke, composite of all-cause mortality or reMI, composite of all-cause mortality, reMI, or stroke | |||||||||
de Boer et al., 2011 [29] | 22 | 6,767 | Patients with acute myocardial infarction | Primary PCI | Fibrinolysis | All-cause mortality | High-risk patients (1) | S | 0/1 |
Fox et al., 2010 [30] | 3 | 5,467 | Patients with non-ST-elevation myocardial infarction | Routine invasive strategy | Selective invasive strategy | Primary | High-risk groups based on baseline characteristics (1) | S | 1/1 |
Composite of CV death or non-fatal MI | |||||||||
Secondary | |||||||||
All-cause death, non-fatal MI alone | |||||||||
Damman et al., 2012 [31] | 3 | 5,467 | Patients with non-ST-elevation myocardial infarction | Routine invasive strategy | Selective invasive strategy | Primary | Age (1) | S | 1/1 |
Composite of CV death or non-fatal MI, CV death, MI | |||||||||
Damman et al., 2012 [32] | 3 | 5,467 | Patients with non-ST-elevation myocardial infarction | Routine invasive strategy | Selective invasive strategy | All-cause mortality | Procedure-related MI, spontaneous MI (2) | S | 1/2 |
Biau et al., 2009 [33] | 6 | 423 | Patients with symptomatic unilateral anterior cruciate ligament injury | Reconstruction with patellar tendon autograft | Reconstruction with hamstring tendon autograft | Primary | Gender, age at surgery, trial effect (3) | S | 2/3 |
Positive pivot-shift test Secondary | |||||||||
Positive Lachman test | |||||||||
Rovers et al., 2005 [34] | 7 | 1,234 | Children with otitis media with effusion | Short-term ventilation tubes | Watchful waiting | Mean time spent with effusion, hearing, language development | Hearing level at baseline, history of acute otitis media, upper respiratory infections, attending day care, socioeconomic status, siblings, season, history of breastfeeding, parental smoking (9) | NS | 2/9 |
Salerno et al., 2007 [35] | 4 | 305 | Cirrhotic patients with refractory ascites | Transjugular intrahepatic portosystemic shunt (TIPS) | Paracentesis | Primary | NA | S | NA |
Death from any cause before LT | |||||||||
Secondary | |||||||||
Liver-related death | |||||||||
Staples et al., 2011 [36] | 2 | 209 | Patients with osteoporotic vertebral compression fractures | Vertebroplasty | Sham | Scores for pain and function | Onset of pain, pain scores at baseline (2) | NS | 0/2 |
McCormack et al., 2003 [37] | 25 | 4,165 | Patients with clinical diagnosis of groin hernia for whom surgical management was judged appropriate | Laparoscopic repair | Open repair | Duration of operation, ‘opposite’ method initiated, conversion, hematoma, seroma, wound/superficial infection, mesh/deep infection, port site hernia, vascular injury, visceral injury, length of hospital stay, time to return to usual activities, persisting pain, persisting numbness, hernia recurrence, known death within 30 days of surgery | NA | S | NA |
(Transabdominal preperitoneal repair (TAPP) or totally extraperitoneal repair (TEP)) | |||||||||
Scott et al., 2002 [38] | 11 | 3,347 | Patients with clinical diagnosis of groin hernia for whom surgical management was judged appropriate | Mesh technique | Non-mesh technique | Duration of operation, ’opposite’ method initiated, conversion, hematoma, seroma, wound/superficial infection, serious complications, length of postoperative hospital stay, time to return to usual activities, persisting pain, persisting numbness, hernia recurrence, known death | NA | S | NA |
EU Hernia Trialists Collaboration, 2002 [39] | 35 | 6,901 | Patients with clinical diagnosis of groin hernia for whom surgical management was judged appropriate | Laparoscopic repair, mesh methods | Open repair, non-mesh methods | Hernia recurrence, persisting pain | NA | S | NA |
Gregson et al., 2012 [40] | 8 | 2,186 | Patients with spontaneous supratentorial intracerebral hemorrhage | Surgery | Conservative treatment | Unfavorable outcome | Location of hematoma, time from event, age, Glascow Coma Score, volume of hematoma (5) | NA | 4/5 |