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Table 1 Characteristics of the 22 identified surgical IPDMAs

From: A systematic review of individual patient data meta-analyses on surgical interventions

Author and year RCTs ( n) Patients ( n) Patients Intervention Comparison Outcome Subgroups ( n) Overall effect estimate Significant effect estimates in subgroups ( n/ N)
Jorgenson et al., 2007 [19] 7 2,091 Women with cervical insufficiency Cervical cerclage Expectant management, no cerclage Primary Obstetric history, cervical length (2) NS 0/2
Pregnancy loss or neonatal death before discharge from hospital
Secondary
Preterm delivery and maternal morbidity
Hlatky et al., 2009 [20] 10 7,812 Patients with multivessel coronary disease Coronary artery bypass graft Percutaneous coronary intervention All-cause mortality Age, sex, diabetes, smoking, hypertension, hypercholesterolaemia, PVD, stability of symptoms, previous MI, heart failure, LV function, no. of diseased vessel, proximal LAD, balloon vs. stent (14) NS 2/14
Daniels et al., 2010 [21] 5 862 Patients with chronic pelvic pain Laparoscopic uterosacral nerve ablation (LUNA) No LUNA Derived measure of worst pain level experienced Presence of visual pathology, site of pain, age, parity (4) NS 1/4
Burzotta et al., 2009 [22] 11 2,686 Patients with ST-elevation myocardial infarction (STEMI) Percutaneous coronary intervention with thrombectomy Standard percutaneous coronary intervention Primary Manual vs. non-manual thrombectomy devices, diabetes, primary vs. rescue PCI, treated vs. non-treated with IIb/IIIa-inhibitors, ischemic time, infarct-related artery, pre-PCI TIMI flow (7) S 1/7
All-cause mortality
Secondary
Survival free from MI, TLR, or TVR, major adverse coronary events (MACE), death+MI
Carotid Stenting Trialists’Collaboration, 2010 [23] 3 3,433 Patients with symptomatic carotid stenosis Carotid stenting Endarterectomy Primary Age, sex, diabetes, hypertension, SBP, hypercholesterolaemia, smoking, coronary heart disease, peripheral artery disease, most recent ipsilateral ischemic event, history of stroke, degree of ipsilateral ischemic stroke, contralateral severe carotid stenosis or occlusion, treatment within 14 days, patients recruited per center, center recruitment rate (16) S 1/16
Any stroke or death
Secondary
Disabling stroke or death, all-cause death, any stroke, myocardial infarction, severe local hematoma, severe wound infection
Middleton et al., 2010 [24] 17 2,814 Patients with heavy menstrual bleeding Hysterectomy, endometrial destruction (1st & 2nd generation), levonorgestrel releasing intra-uterine system (MIRENA) Endometrial destruction (1st & 2nd generation), levonorgestrel releasing intra-uterine system (MIRENA) Dissatisfaction rates Uterine cavity length, age, presence of fibroids/polyps, parity, baseline bleeding score (5) S 1/5
Mercado et al., 2005 [25] 4 3,051 Patients with multi-system coronary artery disease Percutaneous coronary intervention with multiple stenting Coronary artery bypass graft Primary Age, gender, diabetes, smoking, number of diseased vessels (5) NS 0/5
Composite of death, MI, or stroke at 1 year FU
Secondary
Death, composite of death or MI, repeat revascularization, composite of death, MI, stroke, and repeat revalscularization
Boersma et al., 2006 [26] 22 6,767 Patients with acute myocardial infarction PCI Fibrinolysis All-cause mortality Age, sex, diabetes, prior MI, MI location, heart rate, SBP, fibrinolytic agent, front-loaded tPA, site volume (11) S 1/11
Timmer et al., 2007 [27] 19 6,315 Patients with acute myocardial infarction PCI Fibrinolysis Death, recurrent MI, death or recurrent MI, stroke Diabetes (1) S 0/1
de Boer et al., 2010 [28] 22 6,767 Patients with acute myocardial infarction Primary PCI Fibrinolysis Primary Age (1) S 0/1
All-cause mortality
Secondary reMI, stroke, composite of all-cause mortality or reMI, composite of all-cause mortality, reMI, or stroke
de Boer et al., 2011 [29] 22 6,767 Patients with acute myocardial infarction Primary PCI Fibrinolysis All-cause mortality High-risk patients (1) S 0/1
Fox et al., 2010 [30] 3 5,467 Patients with non-ST-elevation myocardial infarction Routine invasive strategy Selective invasive strategy Primary High-risk groups based on baseline characteristics (1) S 1/1
Composite of CV death or non-fatal MI
Secondary
All-cause death, non-fatal MI alone
Damman et al., 2012 [31] 3 5,467 Patients with non-ST-elevation myocardial infarction Routine invasive strategy Selective invasive strategy Primary Age (1) S 1/1
Composite of CV death or non-fatal MI, CV death, MI
Damman et al., 2012 [32] 3 5,467 Patients with non-ST-elevation myocardial infarction Routine invasive strategy Selective invasive strategy All-cause mortality Procedure-related MI, spontaneous MI (2) S 1/2
Biau et al., 2009 [33] 6 423 Patients with symptomatic unilateral anterior cruciate ligament injury Reconstruction with patellar tendon autograft Reconstruction with hamstring tendon autograft Primary Gender, age at surgery, trial effect (3) S 2/3
Positive pivot-shift test Secondary
Positive Lachman test
Rovers et al., 2005 [34] 7 1,234 Children with otitis media with effusion Short-term ventilation tubes Watchful waiting Mean time spent with effusion, hearing, language development Hearing level at baseline, history of acute otitis media, upper respiratory infections, attending day care, socioeconomic status, siblings, season, history of breastfeeding, parental smoking (9) NS 2/9
Salerno et al., 2007 [35] 4 305 Cirrhotic patients with refractory ascites Transjugular intrahepatic portosystemic shunt (TIPS) Paracentesis Primary NA S NA
Death from any cause before LT
Secondary
Liver-related death
Staples et al., 2011 [36] 2 209 Patients with osteoporotic vertebral compression fractures Vertebroplasty Sham Scores for pain and function Onset of pain, pain scores at baseline (2) NS 0/2
McCormack et al., 2003 [37] 25 4,165 Patients with clinical diagnosis of groin hernia for whom surgical management was judged appropriate Laparoscopic repair Open repair Duration of operation, ‘opposite’ method initiated, conversion, hematoma, seroma, wound/superficial infection, mesh/deep infection, port site hernia, vascular injury, visceral injury, length of hospital stay, time to return to usual activities, persisting pain, persisting numbness, hernia recurrence, known death within 30 days of surgery NA S NA
(Transabdominal preperitoneal repair (TAPP) or totally extraperitoneal repair (TEP))
Scott et al., 2002 [38] 11 3,347 Patients with clinical diagnosis of groin hernia for whom surgical management was judged appropriate Mesh technique Non-mesh technique Duration of operation, ’opposite’ method initiated, conversion, hematoma, seroma, wound/superficial infection, serious complications, length of postoperative hospital stay, time to return to usual activities, persisting pain, persisting numbness, hernia recurrence, known death NA S NA
EU Hernia Trialists Collaboration, 2002 [39] 35 6,901 Patients with clinical diagnosis of groin hernia for whom surgical management was judged appropriate Laparoscopic repair, mesh methods Open repair, non-mesh methods Hernia recurrence, persisting pain NA S NA
Gregson et al., 2012 [40] 8 2,186 Patients with spontaneous supratentorial intracerebral hemorrhage Surgery Conservative treatment Unfavorable outcome Location of hematoma, time from event, age, Glascow Coma Score, volume of hematoma (5) NA 4/5