Factor | Example |
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Study limitations | When conducting our comprehensive systematic review of prognostic factors of headaches in children, we reported for example that the evidence of headache severity as a prognostic factor for persistence of headache had serious limitations. This evidence comes from three studies [22–24] and all of them have moderate risk of bias. The sources of potential bias in these studies were: not appropriately accounting for important potential confounders in the design and in the analysis (in [22–24]), not presenting sufficient data to assess adequacy of analysis (in [23, 24]), selective reporting of results (in [23, 24]), and not using any conceptual framework when building a model (in [22–24]). Moreover, we sometimes observed no description of inclusion/exclusion criteria (in [23]), no description of sample frame and recruitment (in [23, 24]), and inadequate information about participation rate (in [22–24]). |