Table 2 Diagnostic accuracy of tests for fibrosis

Platelets <140 to <163

8

0.56 (0.28–0.89)

0.91 (0.69–1.0)

6.3 (2.3–14)

0.48 (0.16–0.78)

 With additional data

10^a

0.57 (0.28–0.89)

0.91 (0.58–1.0)

6.3 (1.64–35)

0.48 (0.16–0.78)

API >3.5 or ≥4.0

5

0.70 (0.52–0.82)

0.70 (0.51–0.77)

2.3 (1.7–2.7)

0.43 (0.34–0.67)

 With additional data

6^a

0.64 (0.52–0.82)

0.69 (0.51–0.77)

2.0 (1.7–2.7)

0.53 (0.34–0.67)

API ≥6.0

5/3^b

0.51 (0.19–0.75)

0.90 (0.58–0.96)

5.1 (1.8 – 7.3)

0.54 (0.43–0.94)

 With additional data

6^a

0.54 (0.19–0.75)

0.88 (0.58–0.96)

4.5 (1.4 – 7.3)

0.52 (0.43–0.94)

APRI ≥0.5 to >0.55

28

0.81 (0.29–0.98)

0.55 (0.10–0.94)

1.8 (1.1–4.8)

0.35 (0.08–0.78)

 With additional data

40^c

0.79 (0.29–0.98)

0.56 (0.10–1.0)

1.8 (1.0–7.5)

0.56 (0.07–0.93)

AST: ALT ratio >1.0

5

0.35 (0.08–0.45)

0.77 (0.62–1.0)

1.5 (1.1–15)

0.84 (0.84–0.98)

 With additional data

8^a,c

0.36 (0.08–0.59)

0.80 (0.48–1.0)

1.7 (1.1–14)

0.81 (0.65–0.98)

ELF >8.75, >9.0, or >9.78

3

0.85 (0.84–0.86)

0.70 (0.62–0.80)

2.8 (2.3–4.2)

0.21 (0.19–0.23)

 With additional data

3^a

0.84 (0.62–0.85)

0.80 (0.70–0.86)

4.2 (2.8–4.4)

0.20 (0.19–0.45)

FIB-4 > 1.26 or ≥1.45

6

0.64 (0.62–0.86)

0.68 (0.54–0.75)

2.0 (0.88–2.6)

0.53 (0.21–1.3)

 With additional data

9^c

0.64 (0.57–0.86)

0.68 (0.28–0.85)

2.0 (0.88–3.7)

0.53 (0.21–1.3)

FIB-4 > 3.25

4

0.50 (0.28–0.86)

0.79 (0.59–0.99)

2.4 (1.3 – 28)

0.63 (0.21–0.80)

 With additional data

7^c

0.28 (0.11–0.86)

0.97 (0.59–1.0)

9.3 (1.3 – 28)

0.74 (0.21–0.89)

FibroIndex >1.25

3

0.94 (0.62–0.97)

0.40 (0.40–0.48)

1.6 (1.2–1.6)

0.15 (0.08 – 0.79)

 With additional data

6^c

0.64 (0.54–0.97)

0.57 (0.40–1.0)

1.5 (1.2–2.2)

0.62 (0.08 – 0.79)

FibroIndex >2.25 or ≥2.25

3

0.30 (0.17–0.36)

0.97 (0.97–1.0)

10,12,∞

0.72 (0.66–0.83)

 With additional data

4^c

0.24 (0.14–0.36)

0.99 (0.97–1.0)

10,12,∞

0.78 (0.66–0.87)

FibroMeter >0.419 to >0.59

3

0.69 (0.64–0.80)

0.81 (0.76–0.81)

3.6 (3.4–3.6)

0.38 (0.26–0.44)

 With additional data

5^c

0.80 (0.64–0.87)

0.76 (0.64–0.81)

3.3 (2.4–3.6)

0.26 (0.21–0.44)

FibroTest >0.10 to >0.22

6

0.92 (0.88–0.97)

0.38 (0.27–0.56)

1.5 (1.3–1.9)

0.21 (0.11 – 0.28)

 With additional data

9^c

0.92 (0.64–0.98)

0.46 (0.21–1.0)

1.7 (1.2–2.2)

0.17 (0.11 – 0.39)

FibroTest >0.70 or >0.80

5

0.22 (0.20–0.50)

0.96 (0.95–0.98)

5.5 (5.5–13)

0.81 (0.53–0.82)

 With additional data

10^a,c

0.38 (0.20–0.94)

0.95 (0.36–0.98)

7.6 (1.4–13)

0.65 (0.12–0.82)

Forns Index >4.2 to >4.57

14

0.88 (0.57–0.94)

0.52 (0.20–0.77)

1.8 (1.2–2.2)

0.22 (0.12–0.64)

 With additional data

16^a,c

0.89 (0.42–0.94)

0.51 (0.20–0.77)

1.8 (0.54–2.2)

0.23 (0.12–2.6)

Forns Index >6.9

10

0.36 (0.18–0.61)

0.94 (0.66–1.0)

6.5 (1.6–18)

0.68 (0.56–0.92)

 With additional data

14^c

0.40 (0.18–0.81)

0.95 (0.33–1.0)

7.4 (1.2–18)

0.63 (0.22–0.92)

Hepascore >0.46 to ≥0.55

5

0.66 (0.54–0.82)

0.79 (0.65–0.86)

3.1 (2.3–4.5)

0.43 (0.28–0.55)

 With additional data

8^c

0.65 (0.54–0.82)

0.80 (0.65–0.86)

3.2 (2.3–4.5)

0.44 (0.28–0.55)

Lok Index >0.17 or >0.20

0

NA

NA

NA

NA

 With additional data

3^c

0.58 (0.48–0.82)

0.80 (0.58–0.81)

2.9 (2.0–3.1)

0.53 (0.31–0.65)