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Table 3 Diagnostic accuracy of tests for cirrhosis

From: Impact of contacting study authors to obtain additional data for systematic reviews: diagnostic accuracy studies for hepatic fibrosis

Fibrosis test (cutoff)

Number of samples

Sensitivity (median, range)

Specificity (median, range)

Positive likelihood ratio (median, range)

Negative likelihood ratio (median, range)

Platelets <140 to <155

9

0.78 (0.41–0.93)

0.87 (0.84–0.94)

6.0 (2.8–93)

0.25 (0.07–0.63)

 With additional data

10a

0.77 (0.41–0.93)

0.86 (0.57–0.99)

5.5 (1.6–93)

0.27 (0.07–0.63)

API ≥6.0

5/3b

0.67 (0.43–0.80)

0.87 (0.81–0.93)

5.2 (2.7–10)

0.38 (0.22–0.68)

 With additional data

6a

0.64 (0.12–0.80)

0.88 (0.81–0.99)

5.3 (2.7–17)

0.41 (0.22–0.88)

APRI >1.0 or ≥1.0

19

0.77 (0.33–1.0)

0.75 (0.30–0.87)

3.1 (1.4–4.9)

0.31 (0–0.77)

 With additional data

30/29b,c

0.75 (0.13–1.0)

0.77 (0.30–1.0)

3.2 (1.4–10.6)

0.33 (0–0.89)

AST: ALT ratio >1.0

17

0.36 (0.12–0.78)

0.92 (0.59–1.0)

4.5 (1.0 – 31)

0.70 (0.47–1.0)

 With additional data

19a

0.39 (0.10–0.78)

0.93 (0.59–1.0)

5.6 (1.0 – 31)

0.66 (0.23–1.0)

FIB-4 > 1.45

1

0.90

0.58

2.1

0.17

 With additional data

4c

0.89 (0.87–1.0)

0.58 (0.40–0.70)

2.1 (1.7–2.9)

0.19 (0.0–0.23)

FIB-4 > 3.25

1

0.55

0.92

6.9

0.49

 With additional data

5c

0.49 (0.40–0.55)

0.93 (0.91–0.95)

6.4 (5.7–8.9)

0.60 (0.49–0.63)

FibroTest >0.56 or >0.66

2

0.85 and 0.82

0.74 and 0.77

3.3 and 36

0.20 and 0.23

 With additional data

7c

0.83 (0.27–0.91)

0.74 (0.65–1.0)

3.6 (2.6–3.6)

0.23 (0.11–0.73)

FibroTest >0.73, >0.75, >0.862

7

0.56 (0.30–1.0)

0.81 (0.24–0.96)

2.9 (1.2–10)

0.54 (0.0–0.79)

 With additional data

10a,c

0.49 (0.11–0.86)

0.89 (0.55–1.0)

4.3 (1.2–11)

0.57 (0.20–0.89)

Forns Index >4.2

1

0.98

0.27

1.3

0.07

 With additional data

6c

0.66 (0.27–1.0)

0.31 (0–1.0)

1.4 (0.27–1.5)

0.07 (0–0.66)

Forns Index >6.9

1

0.67

0.91

7.4

0.36

 With additional data

3c

0.66 (0.53–0.67)

0.87 (0.86–0.91)

5.2 (4.2–7.4)

0.39 (0.36–0.53)

Lok Index ≥0.20 or >0.26

6

0.90 (0.67–1.0)

0.50 (0.30–0.82)

1.8 (1.0–4.8)

0.21 (0–0.94)

 With additional data

7c

0.90 (0.67–1.0)

0.53 (0.30–0.82)

1.9 (1.0–4.8)

0.19 (0–0.94)

Lok Index ≥0.5 or >0.6

7

0.53 (0.40–0.79)

0.88 (0.60–0.95)

4.4 (1.3 – 11)

0.53 (0.24–0.80)

 With additional data

8c

0.53 (0.23–0.79)

0.91 (0.60–0.97)

5.8 (1.3 – 11)

0.52 (0.24–0.80)

  1. Values in italics indicate a change to above or below a cutoff of 5.0 for positive likelihood ratio or 0.20 for negative likelihood ratio.
  2. ALT serum alanine aminotransferase, API age platelet index, APRI aspartate aminotransferase to platelet ratio index, AST aspartate aminotransferase.
  3. aAdditional data for study(s) with discrepancy in reported data.
  4. bThe first number is the number of samples for sensitivity/the second number is the number of samples for specificity.
  5. cAdditional data for study(s) without 2 × 2 tables.