Table 1 Proposed search strategy of ovid

Search strategy

1

scleroderma.mp.

2

systemic sclerosis.mp.

3

exp scleroderma, systemic/

4

exp scleroderma, localized/

5

or/1-4

6

risk.mp.

7

exp risk/

8

((factor$ or feature$ or aspect$ or characteristic$) adj4 (risk)).mp.

9

exp silicon dioxide/

10

exp silicones/

11

exp antacids/

12

exp solvents/

13

organic solvent$.mp.

14

exp epoxy resins/

15

welding fume$ or welding gas*.mp.

16

exp anorexigenic drugs/

17

exp pentazocine/

18

exp bromocriptine/

19

exp tryptophan/

20

exp pesticides/

21

exp vibration/

22

hand vibration or arm vibration.mp.

23

exp alcohol drinking/

24

or/6-23

25

exp gastrointestinal tract/

26

exp gastrointestinal diseases/

27

((problem$ or issue$ or concern$ or complication$) adj3 (alimentary canal or alimentary tract or digestive tube or digestive tract or GI tract)).mp.

28

exp weight loss/

29

uninten** weight loss.mp.

30

((uninten**) adj3 (weight loss)).mp.

31

exp appetite/

32

poor appetite or limited appetite or reduced appetite or sparse appetite.mp. 34. ((poor or limited or reduced or sparse) adj3 (appetite)).mp.

35

exp deglutition disorders/

36

dysphagia or swallowing disorders.mp.

37

exp gastroesophageal reflux/

38

acid reflux.mp.

39

exp colonic pseudo-obstruction/

40

exp duodenal obstruction/

41

exp intestinal obstruction/

42

exp intestinal pseudo-obstruction/

43

chok*.mp.

44

early satiety.mp.

45

bloat* or disten* or bulg* or enlarg* or expan*.mp.

46

exp nausea/

47

exp vomiting/

48

exp constipation/

49

exp diarrhea/

50

((use or prescri** or administ**) adj2 (antibiotic$ or antibacterial$ or antimicrobial$)).mp.

51

exp steatorrhea/

52

exp fecal incontinence/

53

exp parenteral nutrition/

54

or/25-53

55

5 and 24 and 54