Category | Specific items |
---|---|
Death | True death versus surrogate endpoints |
Animal species | Mouse, rat, sheep, pig, other |
Strain | Example for mice: BALB/c versus C57Bl/6 |
Animal age | Mature adult versus middle-aged versus older adult for each species (for example mouse 3 to 10Â months, 10 to 18Â months, 18 to 24Â months) |
Gender | Male versus female versus mix of genders used |
Model of acute lung injury | See Table 2 |
Presence of co-morbidities | Yes versus no |
Severity of lung injury | Lung injury score |
MSC preparation | Fresh versus fresh from previously cryopreserved versus thawed cryopreserved product |
Timing of MSC administration following induction of acute lung injury | 0 to 1Â hours versus 1 to 6Â hours versus >6Â hours |
Route of MSC administration | Intravenous versus intratracheal versus intraperitoneal versus intramuscular |
Type of control | PBS versus normal saline versus fibroblasts versus heat-killed MSCs |
Use of co-interventions | Resuscitation fluids: yes versus no Use of antibiotics in infectious models: yes versus no |
Mechanical ventilation | Yes versus no |
Number of participating study centers | Single versus multi-center |