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Table 2 Meta-regression of study characteristics on log odds ratio for response

From: The safety and efficacy of vortioxetine for acute treatment of major depressive disorder: a systematic review and meta-analysis

Variable

Coefficient

95% confidence interval

Pvalue

ResidualI2

Dosea

0.01

−0.02 to 0.04

0.46

67%

Unpublished

−0.44

−1.04 to 0.16

0.13

74%

Poor quality

0.44

−0.57 to 1.45

0.35

77%

Poor quality or unpublished study

−0.23

−0.84 to 0.38

0.42

78%

Non-US-based study

−0.70

−1.02 to -0.35

0.001

24%

Duration 8 weeks (vs 6 weeks)

0.10

−0.29 to 0.48

0.58

77%

Baseline MADRS score

−0.11

−0.33 to 0.11

0.29

75%

Proportion of study participants non-White

−0.04

−0.05 to -0.02

<0.001

0%

  1. aPlacebo arm partitioned for multi-arm trial.