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Table 1 Electronic search strategy for the identification of relevant studies across multiple databases

From: The impact of chronic pain on opioid addiction treatment: a systematic review protocol

Databases

Search strategies

MEDLINE Search = ______

1. substance related disorders.mp. or Substance-Related Disorders/

 

2. opioid related disorders.mp. or Opioid-Related Disorders/

 

3. Opioid-Related Disorders/or Methadone/or Analgesics, Opioid/or Heroin Dependence/

 

4. 1 or 2 or 3

 

5. methadone.mp. or Methadone/

 

6. Opiate Substitution Treatment/or Naloxone/ or Buprenorphine/or Opioid-Related Disorders/or Narcotic Antagonists/

 

7. buprenorphine.mp. or Buprenorphine/

 

8. naltrexone.mp. or Naltrexone/

 

9. Substance Abuse Treatment Centers/or Heroin/or Heroin Dependence/or Opioid-Related Disorders/or Randomized Controlled Trials as Topic/or Methadone/

 

10. opioid substitution treatment.mp. or Opiate Substitution Treatment/

 

11. Buprenorphine/or Analgesics, Opioid/or Opioid-Related Disorders/or Methadone/or Heroin Dependence/

 

12. 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12

 

13. chronic pain.mp. or Chronic Pain/

 

14. 4 and 13 and 4

 

15. limit 15 to humans

Web of Science Search = ______

1. Topic = (“methadone” OR “methadone maintenance therapy” OR “naltrexone” OR “suboxone” OR “buprenorphine” OR “heroin assisted treatment”)

2. Topic = (“opioid dependence” or “addiction”)

1. Topic = (“chronic pain” OR “pain” OR “opioid induced hyperalgesia”)

2. 1 AND 2 AND 3

EMBASE = _____

1. methadone treatment/or methadone.mp. or methadone/or methadone plus naloxone/

2. heroin dependence/or maintenance therapy/or methadone/or opiate addiction/or diamorphine/or methadone treatment/

3. buprenorphine/or buprenorphine.mp.

4. naltrexone.mp. or morphine sulfate plus naltrexone/or naltrexone/

5. opioid substitution treatment.mp. or opiate substitution treatment/

6. methadone/ or diamorphine/or heroin dependence/

7. levomethadyl acetate.mp. or levacetylmethadol/

8. 1 or 2 or 3 or 4 or 5 or 6 or 7

9. substance related disorder.mp. or addiction/

10. naltrexone/ or buprenorphine/or opioid addiction.mp. or methadone/

11. 9 or 10

12. chronic pain.mp. or chronic pain/

13. 8 and 11 and 12

14. limit 13 to human

PsychINFO Search = _____

1. exp Drug Therapy/or exp Methadone Maintenance/or exp Heroin Addiction/

2. exp Methadone/or exp Naloxone/or exp Drug Therapy/or exp Drug Dependency/or buprenorphine.mp.

3. naltrexone.mp. or exp Naltrexone/

4. exp Heroin Addiction/or exp Drug Rehabilitation/or exp Drug Dependency/or exp Clinical Trials/

5. exp Drug Therapy/or exp Methadone Maintenance/

6. 1 or 2 or 3 or 4 or 5

7. exp Drug Abuse/or substance related disorder.mp. or exp Drug Dependency/

8. substance abuse.mp. or exp Drug Abuse/

9. 7 or 8

10. chronic pain.mp. or exp Chronic Pain/

11. 6 and 9 and 10

Cochrane Library: Cochrane Review and Cochrane Central Register of Controlled Trials = _____

Search title, abstract, keywords:

 

1. “methadone” OR “naltrexone” OR “buprenorphine” OR “opioid substitution treatment” OR “levo-methadyl acetate” OR “heroin assisted treatment” OR “heroin substitution treatment”

 

2. “substance abuse disorder” OR “opioid abuse” OR “substance-related disorder” OR “opioid addiction”

 

3. “chronic Pain” OR “pain” OR “hyperalgesia” OR “neuropathic pain”

Clinical Trials Registry through National Institutes for Health = _____

“methadone” OR “suboxone” OR “Buprenorphine” OR “substitute opioid therapy” OR “naltrexone” OR “heroin assisted treatment” OR “heroin adjustment therapy” AND “opioid addiction” AND “chronic pain”, with additional criteria including: Completed studies, all trials had to be listed as Phase 3, 4

World Health Organization International Clinical Trials Registry Platform Search Portal = _________

“‘opioid addiction’ OR ‘opioid substitution treatment’ OR ‘opioid maintenance treatment’ OR ‘methadone maintenance treatment’” AND “chronic pain”

ProQuest Dissertations and theses Database = _____

“opioid addiction” OR “opioid dependence” AND “pain” OR “Chronic Pain”