Table 2 The strategy will be adapted and executed in the above databases for the full search: Ovid MEDLINE, CINAHL@ VIA EBSCOHOST, EMBASE@ VIA OBID, AND Cochrane Library

1.

Acute Kidney Injury/th

2.

Hemodiafiltration/

3.

Renal Dialysis/

4.

Renal Replacement Therapy/

5.

(dialys* or hemodialys* or haemodialys*).tw,kf.

6.

(haemodiafiltrat* or haemo diafiltrat* or haemofiltrat* or haemo filtrat* or hemodiafiltrat* or hemo diafiltrat* or hemofiltrat* or hemo filtrat*).tw,kf.

7.

(renal replacement adj2 (therap* or treatm* or support*)).tw,kf.

8.

RRT.tw,kf.

9.

or/1-8

10.

(24h or 24hr* or 24 hour* or 24 hr* or continual* or continuous* or twenty four hour* or twenty four hr* or twentyfour hour* or twentyfour hr*).mp.

11.

and/9-10

12.

CRRT.tw,kf.

13.

or/11-12

14.

Critical Care/

15.

Critical Illness/

16.

exp Intensive Care/

17.

Intensive Care Units/

18.

exp Intensive Care Units, Pediatric/

19.

Multiple Organ Failure/

20.

critical care.tw,kf.

21.

critical* ill*.tw,kf.

22.

(ICU* or NICU* or PICU*).tw,kf.

23.

intensive care.tw,kf.

24.

intensivist*.tw,kf.

25.

(multi* organ adj (disfunction* or dis function* or dysfunction* or dys function* or failure*)).tw,kf.

26.

(multi* system adj (disfunction* or dis function* or dysfunction* or dys function* or failure*)).tw,kf.

27.

or/14-26

28.

and/13,27

29.

animals/ not (animals/ and humans/)

30.

28 not 29

31.

limit 30 to (english or french or german or italian or spanish)

32.

limit 31 to yr="1990-Current"

33.

remove duplicates from 32