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Table 2 Search strategy: Ovid MEDLINE(R) in-process and other non-indexed citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to January 29, 2015

From: The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol

1

exp Child/

2

child*.mp.

3

exp Adolescent/

4

exp Pediatrics/

5

peadiatric*.mp.

6

juvenile.mp.

7

teen*.mp.

8

exp Young Adult/

9

young.tw.

10

young adult*.mp.

11

adolescen*.mp.

12

youth.mp.

13

pediatric*.mp.

14

Or/1 - 13

15

exp Polycystic Ovary Syndrome/

16

polycystic ovar*.mp.

17

pcos.tw.

18

Stein-Leventhal syndrome.mp.

19

exp Hyperandrogenism/

20

exp Hirsutism/

21

Hirsutism.tw.

22

Hyperandrogen$.tw.

23

(polycystic ovar* adj3 (syndrome or disorder or disease)).tw.

24

Or/15 - 23

25

exp metformin/

26

metformin.tw.

27

glucophage.tw.

28

Glumetza.tw.

29

Riomet.tw.

30

fortamet.tw.

31

exp Contraceptives, Oral/

32

oral contraceptiv*.tw.

33

ocp.tw.

34

Yasmin.tw.

35

Desogen.tw.

36

diane.tw.

37

Mircette.tw.

38

Cyclessa.tw.

39

Ortho Tri-Cyclen.tw.

40

Ortho-Cyclen.tw.

41

exp spironolactone/

42

spironolactone.tw.

43

aldactone.tw.

44

exp Flutamide/

45

Flutamide.tw.

46

pioglitazone.mp.

47

actos.tw.

48

exp Life Style/

49

exp Health Promotion/

50

Diet Therapy/

51

exp Exercise/

52

Or/25-51

53

randomized controlled trial.pt.

54

Controlled clinical trial.pt.

55

randomized.ab.

56

placebo.ab.

57

clinical trials as topic.sh.

58

randomly.ab.

59

trial.ti.

60

Or/53 - 59

61

14 and 24 and 52 and 60

62

clomiphene.ti.

63

pregnancy.ti.

64

62 or 63

65

61 not 64

Embase 1974 to 2015 January 27

1

child*.mp.

2

peadiatric*.mp.

3

juvenile.mp.

4

teen*.mp.

5

exp Young Adult/

6

young.tw.

7

young adult*.mp.

8

adolescen*.mp.

9

youth.mp.

10

pediatric*.mp.

11

exp pediatrics/

12

adolescent/

13

child/

14

1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13

15

exp ovary polycystic disease/

16

polycystic ovar*.mp.

17

PCOS.mp.

18

Stein-Leventhal syndrome.mp.

19

exp hirsutism/

20

Hirsutism.tw.

21

exp hyperandrogenism/

22

Hyperandrogen$.tw.

23

exp metformin/

24

metformin.tw.

25

glucophage.tw.

26

Glumetza.tw.

27

Riomet.tw.

28

fortamet.tw.

29

exp oral contraceptive agent/

30

oral contraceptiv*.tw.

31

ocp.tw.

32

Yasmin.tw.

33

Desogen.tw.

34

diane.tw.

35

Mircette.tw.

36

Cyclessa.tw.

37

Ortho Tri-Cyclen.tw.

38

Ortho-Cyclen.tw.

39

exp spironolactone/

40

aldactone.tw.

41

exp flutamide/

42

exp pioglitazone/

43

pioglitazone.tw.

44

actos.tw.

45

exp lifestyle/

46

exp health promotion/

47

exp diet therapy/

48

exp exercise/

49

23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43 or 44 or 45 or 46 or 47 or 48

50

random.tw.

51

placebo.mp.

52

Double blind.tw.

53

Single blind.tw.

54

50 or 51 or 52 or 53

55

pregnancy.ti.

56

clomiphene.ti.

57

15 or 16 or 17 or 18 or 19 or 20 or 21 or 22

58

55 or 56

59

14 and 49 and 54 and 57

60

59 not 58

Cochrane central: search up to 30/01/2015 20

#1 MeSH descriptor: [Adolescent] explode all trees

#2 MeSH descriptor: [Child] explode all trees

#3 MeSH descriptor: [Young Adult] explode all trees

#4 young adult.tw

#5 adolescen*.tw

#6 #1 or #2 or #3 or #4 or #5

#7 MeSH descriptor: [Polycystic Ovary Syndrome] explode all trees

#8 Stein Leventhal Syndrome or Polycystic Ovar* or PCOS. tw

#9 MeSH descriptor: [Hirsutism] explode all trees

#10 MeSH descriptor: [Hyperandrogenism] explode all trees

#11 hyperandrogen*. tw

#12 Hirsutism. tw

#13 #6 or #7 or #8 or #9 or #10 or #11 or #12

#14 metformin or glucophage or pioglitazone or oral contraceptive pill or OCP or Ortho Tri-Cyclen or Ortho-CyclenCyclessa or Mircette or Yasmin or diane or Desogen or Flutamide or spironolactone or aldactone. tw

#15 MeSH descriptor: [Metformin] explode all trees

#16 MeSH descriptor: [Contraceptives, Oral, Hormonal] explode all trees

#17 MeSH descriptor: [Spironolactone] explode all trees

#18 MeSH descriptor: [Flutamide] explode all trees

#19 MeSH descriptor: [Life Style] explode all trees

#20 #14 or #15 or #16 or #17 or #18 or #19

#21 #7 and #13 and #20 in Trials