Table 1 Search strategy of MEDLINE via Ovid

1.

scleroderma.mp.

2.

systemic sclerosis.mp.

3.

exp scleroderma, systemic/

4.

exp scleroderma, localized/

5.

or/1-4

6

risk.mp.

7.

exp risk/

8.

((factor$ or feature$ or aspect$ or characteristic$) adj4 (risk)).mp.

9.

exp silicon dioxide/

10.

exp silicones/

11.

exp antacids/

12.

exp solvents/

13.

organic solvent$.mp.

14.

exp epoxy resins/

15.

welding fume$ or welding gas*.mp.

16.

exp anorexigenic drugs/

17.

exp pentazocine/

18.

exp bromocriptine/

19.

exp tryptophan/

20.

exp pesticides/

21.

exp vibration/

22.

hand vibration or arm vibration.mp.

23.

exp alcohol drinking/

24.

or/6-23

25.

exp gastrointestinal tract/

26.

exp gastrointestinal diseases/

27.

((problem$ or issue$ or concern$ or complication$) adj3 (alimentary canal or alimentary tract or digestive tube or digestive tract or GI tract)).mp.

28.

exp weight loss/

29.

uninten** weight loss.mp.

30.

((uninten**) adj3 (weight loss)).mp.

31.

exp appetite/

32.

poor appetite or limited appetite or reduced appetite or sparse appetite.mp. 34. ((poor or limited or reduced or sparse) adj3 (appetite)).mp.

35.

exp deglutition disorders/

36.

dysphagia or swallowing disorders.mp.

37

exp gastroesophageal reflux/

38.

acid reflux.mp.

39.

exp colonic pseudo-obstruction/

40.

exp duodenal obstruction/

41.

exp intestinal obstruction/

42.

exp intestinal pseudo-obstruction/

43.

chok*.mp.

44.

early satiety.mp.

45.

bloat* or disten* or bulg* or enlarg* or expan*.mp.

46.

exp nausea/

47.

exp vomiting/

48.

exp constipation/

49.

exp diarrhea/

50.

((use or prescri** or administ**) adj2 (antibiotic$ or antibacterial$ or antimicrobial$)).mp.

51.

exp steatorrhea/

52.

exp fecal incontinence/

53.

exp parenteral nutrition/

54.

or/25-53

55.

5 and 24 and 54