From: Community-onset sepsis and its public health burden: a systematic review
Study ID country | Cohort and study characteristics | Study design and duration of follow-up | Type of sepsis | Incidence – overall (total cohort) | Methodological quality (high, acceptable, low) | ||
---|---|---|---|---|---|---|---|
N of cases per 100,000 population per year [95% CI] | CIP % per hospitalisation or ED visit per year [95% CI] | IDR (N of cases per 100,000 p-y) [95% CI] | |||||
Esteban 2007 [46] Spain | Geographic scope | Prospective cohort study | Non-severe | 367 [352, 384] | 13.28% [12.76, 13.81] | NR | Acceptable quality |
City/municipal | Severe | 104 [96, 113] | 3.76% [3.47, 4.06] | NR | |||
FU: 4 months | |||||||
Setting | Septic shock | 31 [27, 36] | 1.11% [0.95, 1.28] | NR | |||
ICU, hospital ward | |||||||
Cohort denominator | |||||||
N (population)=573,149 | |||||||
N (hospitalisations)=15,852 | |||||||
Ginde 2013 [47] The USA | Geographic scope | Retrospective cohort study | Severe | NR | 0.40% [0.39, 0.41] | NR | Low quality |
Nationwide | |||||||
Setting | FU: 5 years | ||||||
ED | |||||||
Cohort denominator | |||||||
N (population)=NR | |||||||
N (all ED visits)=87,500,000 | |||||||
Harrison 2006 [11] The UK | Geographic scope | Retrospective cohort study | Severe | 66 [NR]μ | 27.87% [27.52, 28.24] | NR | Acceptable quality |
Nationwide | |||||||
Setting | FU: 2 years | ||||||
ICU, combination of ICU with HDU | |||||||
Cohort denominator | |||||||
N (population)=NR | |||||||
N (hospitalisations)=59,527 | |||||||
Henriksen 2015a [42] Denmark | Geographic scope | Prospective cohort study | All | 727 [693, 762] | NR | 731 [697, 767] | Acceptable quality |
City/municipal | Non-severe | 264 [243, 285] | NR | 265 [245, 287] | |||
Setting | FU: 1 year | Severe | 455 [428, 482] | NR | 457 [430, 485] | ||
ED, ICU | Septic shock | 9 [6, 13] | NR | 9 [6, 14] | |||
Cohort denominator | |||||||
N (population )=235,598 | |||||||
N (hospitalisations)=8,358 | |||||||
Husak 2010 [48] Canada | Geographic scope | Retrospective cohort study | All | 103 [NR]μ | NR | NR | Low quality |
Nationwide | Non-severe | 64 [NR]μ | NR | NR | |||
Setting | FU: 5 years | Severe | 40 [NR]μ | NR | NR | ||
ED, ICU, hospital ward | |||||||
Cohort denominator | |||||||
N (population or hospitalisations)=NR | |||||||
Nygard 2014 [49] Norway | Geographic scope | Prospective cohort study | Severe | 50 [NR]μ | 0.22% [NR]μ | NR | Low quality |
City/municipal | |||||||
Setting | FU: 1 year | ||||||
ED, ICU, HDU, combination of ICU with HDU | |||||||
Cohort denominator | |||||||
N (population or hospitalisations)=NR | |||||||
Page 2015 [50] The USA | Geographic scope | Retrospective cohort study | Severe | NR | CA-SS | NR | Low quality |
Nationwide | 5.75% [5.72, 5.77] | ||||||
Setting | FU: 1 year | HCA-SS | |||||
NR | 2.37% [2.35, 2.38] | ||||||
Cohort denominator | |||||||
N (population)=NR | |||||||
N (hospitalisations)=3,355,753 | |||||||
Wang 2012 [36] REGARDS-sepsis cohort study 2012-2015β The USA | Geographic scope | Prospective cohort study | Non-severe | 514 [489, 539] | NA | 800 [760, 840] | Acceptable quality |
Nationwide | |||||||
Setting | FU: 9-10 years | ||||||
Hospital ward, ED | |||||||
Cohort denominator | |||||||
N (population)=30,239 | |||||||
N (hospitalisations)=NR | |||||||
Seymour 2012 [51]The USA | Geographic scope | Retrospective cohort study | Severe | NR | Entire 10-year cohort | NR | Low quality |
Regional (within-State) | 3.25% [3.20, 3.31] | ||||||
Setting | FU: 10 years | One-year cohort | |||||
Pre-hospital emergency medical services | 4.93% [4.73, 5.13] | ||||||
Cohort denominator | |||||||
N (population)= NR | |||||||
N (emergency encounters)=407,176 | |||||||
Wang 2007 [52] The USA | Geographic scope | Retrospective cohort study | Severe | NR | 0.69% [0.61, 0.77] | NR | Low quality |
 | Nationwide | ||||||
Setting | FU: 4 years | ||||||
ED | |||||||
Cohort denominator | |||||||
N (population)=NR | |||||||
N (ED visits)=82,883,000 |