Table 2 Quantitative measures of severity of pulmonary hypertension

Direct measurement

Right ventricular systolic pressure (RVSP)

Pulmonary hemodynamics [12, 30]

Continuous

Mean pulmonary arterial pressure (mPAP)

Pulmonary hemodynamics [12, 30]

Continuous

Cardiac output, cardiac index

Cardiac function [12, 30]

Continuous (calculated)

Pulmonary vascular resistance (PVR)

Pulmonary hemodynamics

Continuous (calculated)

Post-mortem tissue collection

Morphometric RV hypertrophy (RV/LV+S)

RV remodeling [12, 30]

Continuous

Echocardiography

Pulmonary artery acceleration time (PAT)

Pulmonary hemodynamics [12, 30]

Continuous

RV free wall thickness

RV remodeling [12, 30]

Continuous

Tricuspid annular plane systolic excursion (TAPSE)

Cardiac function

Continuous

Ratio of deaths/total participants at experimental endpoint

Death

Mortality

Continuous

Survival time relative to induction

Survival

Survival

Continuous