Table 1 Search strategy using MEDLINE 1946 to present with daily update

1

Bipolar Disorder/

33,501

2

bipolar*.tw.

43,114

3

affective disorder*.mp. or Mood Disorders/

24,504

4

manic*.tw.

9456

5

mania.tw.

7439

6

hypomani*.tw.

2075

7

(mixed adj (state* or episode*)).mp. [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]

1096

8

Cyclothymic Disorder/

565

9

cyclothymi*.tw.

751

10

rapid next cycl*.tw.

0

11

schizoaffective.tw.

4195

12

Affective Disorders, Psychotic/or Psychotic Disorders/

40,311

13

unipolar*.tw.

8387

14

1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13

117,677

15

Smoking/or Marijuana Smoking/or Smoking Cessation/

137,906

16

"Tobacco Use"/

394

17

(smok* or tobacco or cigarette* or nicotine).tw.

244,392

18

exp Alcohol Drinking/

55,319

19

alcoholic intoxication/or alcoholism/

78,084

20

(alcohol* or drinking).tw.

281,327

21

marijuana abuse/or exp opioid-related disorders/

24,563

22

Cannabis/

7067

23

designer drugs/or exp street drugs/

10,732

24

exp Sleep/

64,880

25

sleep.tw.

104,983

26

Exercise/or Exercise Therapy/

101,251

27

Physical Exertion/

53,748

28

Motor Activity/

83,896

29

Sports/

25,382

30

(Physical Education and Training).mp. [mp = title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]

12,568

31

exp Diet Therapy/

44,656

32

(diet* adj5 (health* or weight*)).tw.

26,065

33

(calorie adj5 (control or reduc* or restrict*)).tw.

3102

34

food choice*.tw.

2516

35

(exercise* or sport*).tw.

232,095

36

(physical activit* or physical inactivit*).tw.

62,477

37

nutrition*.tw.

179,639

38

Sedentary Lifestyle/

4056

39

(sedentary adj5 (lifestyle or behavio?r*)).tw.

4236

40

(weight adj (loss or reduc* or gain* or change*)).tw.

103,986

41

(drug adj (use* or abus*)).tw.

56,661

42

(diet* adj5 quality).tw.

4443

43

15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42

1,374,954

44

random*.tw.

711,373

45

cross-over studies/or double-blind method/or random allocation/or single-blind method/

248,804

46

Randomized Controlled Trial/

404,345

47

Controlled Clinical Trial/

89,970

48

trial.tw.

368,603

49

groups.tw.

1,376,585

50

(evaluation* or treatment* or intervention*).tw.

4,060,728

51

44 or 45 or 46 or 47 or 48 or 49 or 50

5,446,183

52

14 and 43 and 51

6410

53

limit 52 to english language

5828