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Table 1 Definition of the four levels of evidence by GRADE [15]

From: Chinese herbal medicine for the treatment of primary hypertension: a methodology overview of systematic reviews

Quality level

Definition

High

We are very confident that the true effect lies close to that of the estimate of the effect

Moderate

We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different

Low

Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect

Very low

We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect