AE category | Number of studies | Number of events, HA group | Sample size, HA group | Number of events, placebo group | Sample size, placebo group | Relative risk | 95 % confidence interval |
---|---|---|---|---|---|---|---|
All serious AEs (combined joint and othera) | 8 | 27 | 1056 | 16 | 1017 | 1.39 | (0.78, 2.47) |
Serious AEs, joint (e.g., synovitis) | 5 | 10 | 442 | 8 | 447 | 1.25 | (0.53, 2.94) |
Serious AEs, other (e.g., herpes zoster) | 6 | 17 | 614 | 8 | 570 | 1.52 | (0.70, 3.26) |
All non-serious AEs (combined joint, local non-joint, and other) | 10 | 415 | 1645 | 375 | 1564 | 1.03 | (0.93, 1.15) |
Non-serious AEs, joint (e.g., pain) | 7 | 121 | 559 | 97 | 518 | 1.15 | (0.91, 1.43) |
Non-serious AEs, local non-joint (e.g., erythema) | 6 | 98 | 492 | 79 | 493 | 1.26 | (0.99, 1.60) |
Non-serious AEs, other (e.g., headache) | 6 | 196 | 594 | 199 | 553 | 0.89 | (0.78, 1.03) |