Complications and health-related quality of life after robot-assisted versus open radical cystectomy: a systematic review and meta-analysis of four RCTs

Table 1 Individual study characteristics

Reference	No (ORC/RARC)	Urinary diversion method	Exclusion criteria	Age, years (ORC/RARC)	Mean (%)	Matching outcomes
Nix et al. 2010 [15] USA	20/21	Extra-corporeal	Not surgical candidates Not allowing randomization Preconceived preference for ORC or RARC	69.2/67.4 (mean)	75.6	1,3,6
Parekh et al.^a 2013 [16] USA	20/20	Unclear	Inability to give informed consent, Multiple prior abd and pelvic surgery Morbid obesity Clinical T4 BC LN positive BC or retroperitoneal LN Preexisting condition precluding safe pneumoperitoneum Age <30 or >90 Pregnancy	64.5/69.5 (median)	85	1,3,6
Messer et al.^a 2014 [29] USA	20/20	Unclear		64.5/69.5 (median)	85	5
Bochner et al. 2015 [17] USA	58/60	Extra-corporeal	Contraindication for Trendelenberg Extensive prior abd surgery	65/ 66 (median)	78.8	2,3,5,7
Khan et al. 2016 [18] UK	20/20	Extra-corporeal	Previous pelvic radiation T4 or M1 Contraindication for Trendelenberg Extensive prior abd surgery	66.6/68.6 (mean)	87.5	1,2,3,5,6,7

Outcomes: 1: number of patients with complications within 30 days, 2: number of patients with complications within 90 days, 3: length of stay (days), 4: time back to work, 5: quality of life, 6: number of grade 3–5 complications within 30 days, 7: number of grade 3–5 complications within 90 days
^aSame population in Parekh and Messer

ISSN: 2046-4053