High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis

Table 1 Characteristics of included trials

Trial	Total (n), HFNC/control	Setting	Severity of illness score	Intervention protocol	Control protocol	Protocol duration	Longest follow-up
Frat 2015 [26]	106/207	Medical and surgical ICU	SAPS II; HFNC 25 ± 9, standard 24 ± 9, NIV 27 ± 9	HFNC	Standard oxygen arm and NIV arm	Recovery or intubation	90 days
Jones 2016 [34]	172/150	Emergency Department	NR	HFNC	standard oxygen	Recovery or admission	90 days
Lemiale 2015 [29]	53/49	Immuno-compromised ICU	SAPS II; HFNC 42 (29.5–52), control 37.5 (31.5–46.5)	HFNC	Standard oxygen venturi mask	120 min	ICU stay
Rittayamai 2015 [30]	20/20	Emergency department	NR	HFNC	Standard oxygen	ED stay	60 min
Simon 2014 [31]	20/20	Medical and surgical ICU	SAPS II; HFNC 43 ± 13, control 46 ± 10	HFNC	NIV	15 min pre-, 50 min post-bronchoscopy	28 days
Stephan 2015 [27]	414/416	Post-cardiac surgery ICU	SAPS II; HFNC 29 (27.8–30.1), control 28.8 (27.7–30.0)	HFNC	NIV	NR	ICU stay
Vourc’h 2015 [28]	63/61	Medical and surgical ICU	SAPS II; HFNC 54.5 ± 20.2, control 51.3 ± 16.5	HFNC	Face mask	4 min +	28 days

HFNC high-flow nasal cannulae, NR not reported, ICU intensive care unit, ED emergency department, NIV non-invasive ventilation, SAPS Simplified Acute Physiology Score

ISSN: 2046-4053