High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis

Table 2 Secondary and safety outcome measures

Outcome or subgroup		Participants		Effect estimate (95% CI)	I ² (UCI)
Outcome or subgroup	Studies	Intervention	Control	Effect estimate (95% CI)	I ² (UCI)
Patient tolerance [26, 30]	2	n = 126	n = 227	SMD − 0.63 (− 1.11, − 0.15)	54%
Intubation [26, 27, 29, 31, 34]	5	113/764	176/841	RR 0.85 (0.70, 1.04)	0% (0%, 74%)
Cardio-respiratory arrest [26,27,28, 34]	3	5/341	13/207	RR 0.65 (0.26, 1.62)	0% (0%, 87%)
PaO₂:FiO₂ ^a [26, 27]	2	n = 520	n = 623	MD − 53.34 (− 71.95, − 34.72)	61%
pH^a [26, 27]	2	n = 520	n = 623	MD 0.01 (0.00, 0.01)	36%
PaCO₂ ^a [26, 27]	2	n = 520	n = 623	MD − 0.66 (− 1.47, 0.16)	67%

ISSN: 2046-4053