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Table 3 A priori defined data collection elements

From: Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol

Data collection element

Items

Study Characteristics

Author

Year of publication

Funding support

Country

Study design

Total number of animals used

N per independent intervention group

Species

Strain

Gender

Weight

Mean age

MI model (i.e. LAD ligation, ischemia reperfusion, cryoinjury, microembolism)

Intercurrent illness of animal

Anesthetic administered

Intervention Characteristics

Route of MSC delivery (intravenous, intracoronary, intramyocardial)

Timing of MSC delivery

Frequency of MSC delivery

Source of MSCs (syngenic, allogeneic, xenogenic)

Tissue origin of MSCs (bone marrow, adipose, Wharton’s jelly)

Condition of MSCs (fresh, cryopreserved)

Vehicle

Defining criteria for MSCs