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Table 2 Summary of statistical results for pulmonary tuberculosis (PTB) and extra-pulmonary tuberculosis (EPTB) pathological samples

From: Effectiveness of real-time polymerase chain reaction assay for the detection of Mycobacterium tuberculosis in pathological samples: a systematic review and meta-analysis

Test property

Summary measure of test accuracya (95% CI)

Test for heterogeneity

(χ 2) (df = 24)

(I 2)

p value

PTB (n = 31; b28,406) AUC = 0.99

 Sensitivity

0.82 (0.81–0.83)

586.21

92.8%

< 0.001

 Specificity

0.99 (0.99–0.99)

361.23

91.7%

< 0.001

 Positive likelihood ratio (PLR)

42.77 (28.23–64.81)

285.01

89.5%

< 0.001

 Negative likelihood ratio (NLR)

0.16 (0.12–0.20)

359.13

91.6%

< 0.001

 Diagnostic odds ratio (DOR)

324.26 (189.08–556.09)

242.84

87.6%

< 0.001

EPTB (n = 25; b6974) AUC = 0.96

 Sensitivity

0.70 (0.67–0.72)

272.48

91.20%

< 0.001

 Specificity

0.99 (0.99–0.99)

105.48

77.20%

< 0.001

 Positive likelihood ratio (PLR)

29.82 (17.86–49.78)

75.37

68.20%

< 0.001

 Negative likelihood ratio (NLR)

0.33 (0.26–0.42)

186.30

87.10%

< 0.001

 Diagnostic odds ratio (DOR)

125.20 (65.76–238.36)

70.73

66.10%

< 0.001

  1. χ 2 chi-squared, df degree of freedom, I 2 I-squared, n number of studies, CI confidence interval, AUC area under receiver operating characteristics curve, PTB pulmonary tuberculosis, EPTB extra-pulmonary tuberculosis
  2. aRandom-effects model
  3. bNumber of specimens