Table 1 PICO question and search strategy for MEDLINE (via PubMed)
P | Patients with stage II/III rectal cancer |
I | Neoadjuvant chemoradiotherapy with a platinum derivative added to fluoropyrimidine |
C | Neoadjuvant chemoradiotherapy with a single-agent fluoropyrimidine |
O | Overall survival, disease-free survival |
(neoadjuvant [tw] OR neo-adjuvant [tw] OR preoperative [tw] OR pre-operative [tw] OR “Neoadjuvant Therapy” [MeSH]) AND carboplatin* [tw] OR oxaliplatin* [tw] OR cisplatin* [tw] OR platin* [tw] OR “Carboplatin” [MeSH] OR “Cisplatin” [MeSH] OR “Organoplatinum Compounds” [MeSH] AND ((adenocarcinom* [tw] OR carcinom* [tw] OR cancer [tw] OR malignant growth [tw] OR tumor [tw] OR tumour [tw]) AND (rectum [tw] OR rectal [tw] OR rectum [MeSH])) OR rectal neoplasms [MeSH] AND random* [tw] OR randomized controlled trial [pt] OR RCT [tw] OR “Randomized Controlled Trials as Topic” [MeSH] OR controlled clinical trial [pt] OR clinical trials as topic [mesh: noexp] OR controlled trial [tw] OR clinical trial [tw] OR controlled study [tw] OR control group [tw] OR “Control Groups” [MeSH]) | |