Fig. 2From: B-type natriuretic peptide-guided therapy for heart failure (HF): a systematic review and meta-analysis of individual participant data (IPD) and aggregate dataAll-cause mortality. Unadjusted individual hazards ratios (HR) with 95% confidence intervals (CI) presented within IPD, aggregate data, and overall. Time-CHF reported results separately for patients with heart failure with reduced ejection fraction (HFrEF) [26] and patients with heart failure with preserved ejection fraction (HFpEF) [33]. HR for all-cause mortality was not available for the Protect study [30]. The HR and 95% CI from Guide-It [11] was adjusted for age, sex, left ventricular ejection fraction, NT-proBNP, and the presence of diabetes mellitus. Note: weights are from random effect analysisBack to article page