From: Deworming in non-pregnant adolescent girls and adult women: a systematic review and meta-analysis
Author, year | Sample size | Country | Age (range in years) | Intervention arms | Comparisons in analyses | Study length (months) | Baseline anaemia (%) | Parasite prevalence (%) | Parasite intensity (eggs per gram) |
---|---|---|---|---|---|---|---|---|---|
553 | Bangladesh | 14–66 | 1. 200 mg ferrous fumarate + 200 mg folic acid, 1×/week 2. 400 mg albendazole single dose at week 1 and week 12 3. Interventions 1 + 2 4. Placebo | 2 vs. 4 3 vs. 1a | 5.5 | 85.7 | Ascaris: 47.6 Hookworm: 74.4 Trichuris: 56.8 | Ascaris: 20.8; Hookworm: 57.7; Trichuris: 14.8 | |
Gopaldas 1983 [105] | 170 | India | 5–13 | 1. Placebo 2. Anthelmintic + antiprotozoal 3. Anthelmintic + iron 4. Anthelmintic + iron + vitamin A 5. Iron Anthelmintic: mebendazole 100 mg, 2×/day (3 consecutive days, 2×/4 months Antiprotozoal: tinidazole 50 mg/kg body weight for 3 days consecutively Iron: iron-folic acid (20 mg elemental iron and l00 mcg folic acid), 1×/day for 60 days, repeated at 4 months Vitamin A: one dose of 200,000 I.U.) | 3 vs. 5a | 8 | 93.0 | Any helminth: 11% | NR |
Olds 1999 [83] | 1518 | Philippines, China, Kenya | 5–18 | 1. Placebo (physically identical) 2. Albendazole (single dose 400 mg) 3. Praziquantel (one dose of 40 mg/kg body weight) 4. Albendazole + praziquantel | 2 vs. 1 | 6 | 75.2 | Ascaris: 60.2 Hookworm: 52.1 Trichuris: 81.0 | Generally light infections |
Miguel 2004 [23] | 3903 | Kenya | 6–18 | 1. Albendazole, 400 mg, 2×/year 2. Albendazole, 600 mg, 2×/year + praziquantel 40 mg/kg, 2×/year 3. No treatment | 1 vs 3 | 24 | 4.0 | Ascaris: 42.0 Hookworm: 77.0 Trichuris: 55.0 | Ascaris: 2337 ± 5156; Hookworm: 426 ± 1055; Trichuris: 161 ± 470 |