Skip to main content

Table 1 Associations of mutations in P. falciparum with antimalarial resistance

From: Diagnostic accuracy of molecular methods for detecting markers of antimalarial drug resistance in clinical samples of Plasmodium falciparum: protocol for an update to a systematic review and meta-analysis

Gene

Associated with susceptibility or resistance to

Chloroquine resistance transporter (pfcrt)

Amodiaquine, chloroquine, lumefantrine, quinine

Cytochrome b (pfcytb)

Atovaquone

Dihydrofolate reductase (pfdhfr)

Cycloguanil, proguanil, pyrimethamine

Dihydropteroate synthase (pfdhps)

Sulphadoxine

Kelch 13 (pfk13)

Artemisinins

Multi-drug resistance 1 (pfmdr1)

Amodiaquine, artemisinins, chloroquine, halofantrine, lumefantrine, mefloquine, piperaquine, quinine

Plasmepsin 2 (pfpm2)

Piperaquine

Plasmepsin 3 (pfpm3)

Piperaquine