Population(s)
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Individuals with dementia and BPSD living in the community, long term care, or in specialized longer stay settings
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Intervention
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All anticonvulsants for BPSD including valproic acid, gabapentin, pregabalin, carbamazepine, phenytoin, topiramate, levetiracetam, zonisamide, oxcarbazepine, lamotrigine, and phenobarbital. Benzodiazepines excluded
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Control
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Placebo, no intervention, or other active treatments including both non-pharmacologic or pharmacologic treatments
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Outcomes
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Primary outcomes: We will consider studies that use validated measures of BPSD such as
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1. Neuropsychiatric Inventory [19].
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2. Cohen-Mansfield Agitation Inventory [20]
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3. Brief Psychiatric Rating Scale [21]
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4. Clinical Global Impression Scale
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Secondary outcomes:
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1. Caregiver burden and quality of life
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2. Placement in long term care facility from home.
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3. Serious adverse effects
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4. Treatment discontinuation due to serious adverse effects
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Study design
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Randomized control trials and crossover trials.
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Timing
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Any duration of follow-up longer than 2 weeks.
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