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Table 3 Overview of selected studies

From: Efficacy of commercially available biological agents for the topical treatment of cervical intraepithelial neoplasia: a systematic review

 

Author

Treatment regimen

Placebo

Delivery system (by investigator/patient)

Disease

Number treated/placebo

Regression treated (%)/placebo (%)

Remission treated (%)/placebo (%)

FU, after end of treatment

1

Sidhu 1997 [14]

20 mg of 5-FU for 24 h (one application)

Cytotoxic drug delivery system without 5FU

Bilaminar bioadhesive polymeric film

CIN1–2

48/46

67%/72% (p = 0.76)

 

6 months

2

Rahangdale 2014 [13]

2 g of 5% 5-FU once every 2 weeks for a total of 16 weeks (eight applications)

Observation, no placebo

Vaginal applicator (+ tampon) (by patient)

CIN2

28/27

93%/56% (p = 0.01)

86%/44%

10 weeks

3

Meyskens 1994 [28]

1.0 ml of 0.375% atRA or a placebo cream for 24 h. Start: daily for 4 days; months 3 and 6: daily for 2 days (eight applications)

Polyethylene glycol 400, butylated hydroxytoluene, 55% alcohol

Cervical cap + collagen sponge (by investigator)

CIN2 CIN3

75/66 40/51

 

43%/27% (p = 0.41) 25%/31% (p = 0.33)

21 months

4

Ruffin 2004 [29]

0.16–0.28% - 0.36% atRA or placebo daily for four consecutive days (four applications)

Same carrier base to compound atRA

cervical cap + collagen sponge (by investigator)

CIN2 CIN3

29–32–34/24 16–12–13/14

83–87–74%/70%

57–58–35%/57%

62–50–50% /62%

44–50–14/21%

11 weeks

5

Van Pachterbeke 2009 [16]

3 ml cidofovir 2% in Intrasite gel (for 4 h) or placebo, three applications in 1 week

Sterile water + Intrasite gel

Cervical cap (by investigator)

CIN2–3

23/25

 

61%/20% (p = 0.01)

6 weeks

6

Grimm 2012 [30]

6.25 mg imiquimod (overnight)

2 g Adeps solidus

Vaginal suppositories (by patient)

CIN2–3

28/27

79%/41% (p = 0.009)

50%/15% (p = 0.08)

4 weeks

week 1–2: 1 suppo/w

week 3–4: 2 suppo/w

week 5–16: 3 suppo/w

(max. 42 applications)

  1. CIN cervical intraepithelial neoplasia, FU follow-up, mIU million international units