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Table 4 Reasons for exclusion of studies

From: Efficacy of commercially available biological agents for the topical treatment of cervical intraepithelial neoplasia: a systematic review

Reasons for exclusion

Studies

In vitro study on cervical cancer lines

Zou 2003

Less than 20 women involved

Barten1987; Pride 1982; Choo1986; Hubert 2012; Snoeck 2000; Choo 1985

Paper not traceable (no abstract available)

Marianowski 1976; Misiewicz 1969

Phase I clinical trial

Meyskens 1986; Weiner 1986; Cheng 2001

Photodynamic therapy

Barnett 2003; Choi 2013; Choi 2014; Fu 2016; Hillemanns 2015, Hillemanns 1999; Hillemanns 2014; Hillemanns 2008; Hillemanns 2015; Paheernik1998; Soergel 2010; Yamaguchi 2005; Wang 2010; Monk 1997; Soergel 2008

Restrospective case series

Geisler 2016

Review, and/or not a randomized clinical trial

Cinel 1991; Snoeck 2001; Chakalova 2004; Tao 2014

Surgical treatment utilized

Pachman 2012; Koeneman 2016; Maiman 1999; Gleeson 1992

Vulvar and/or vaginal intraepithelial neoplasia also treated

Diaz-Arrastia 2001; Lin 2012; Yliskoski 1990

Study on cervical condylomatosis

Alberico 1985

Study on HPV infection only

Shukla 2009; Iljazovic 2006; Niwa 2003; Chen 2013; Cappello 1991; Schettino 2013

Systemic route also utilized

Rotola 1995; Valencia 2011; Follen 2001; Vlastos 2005; Sartor 1993; Osnengo 1990; Alvarez 2016