Study dates (years from T0; bold= ‘baseline’) | Alcohol category* (bold=referent) | Cognitive function (bold=selected result) | ||||||||||||||||||||||||
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Study ID (sample size at T0; % female) | Age (T0) | T0 | T1 | T2 | T3 | T4 | T5 | TX | Age final follow-up | Length of follow-up from b/l | 0 to < 10 g/week | ≥ 10 g/week to < 10 g/day | ≥ 10 to < 20 g/day | ≥ 20 to < 30 g/day | ≥ 30 to < 40 g/day | ≥ 40 to < 50 g/day | ≥ 50 g/day | Global function | MCI diagnosis | Complex attention | Executive function | Learning and memory | Language | Perceptual motor ability | Social cognition | Outcome description (details of selected result) |
Arntzen 2010 [44] (5033; 56%)** | 58 (mean) | A | C (~7) | ~65 | ~7 | X | X | X | X | SCD: learning and memory (immediate and delayed recall) | ||||||||||||||||
Downer 2015 [45] (664; 56%)** | 42 (mean) | A | C (~28) | C (~34) | 75 (mean) | ~34 | X | X | X | X | X | X | X | GCF: Average of Z-scores on 11 tests (incl. memory, executive function, language, complex attention) | ||||||||||||
Hassing 2018 [46] (305; 56%) critical RoB | ~56–66 | A | C (~24) | C (~26) | C (~28) | C (~30) | C (~32) | 83 (mean) | ~32 | X | X | X | X | X | X | GCF: MMSE score (change over time) | ||||||||||
Heffernan 2016 [47] (821; 55%)** | 70–90 | A, C | C (~2) | C (~2) | ~74–94 | ~4 | X | X | X | X | X | X | X | X | SCD: learning and memory (delayed recall) | |||||||||||
Hogenkamp 2014 [48] (652; 100%) | 70 | A, C | C (~7) | 77 | ~7 | X | X | X | X | X | X | SCD: executive function (TMT-B) | ||||||||||||||
Horvat 2015 [49] (28,947; 55%)** | 45–69 | A, C | C (~4) | 47–78 | ~4 | X | WM | W | WM | M | X | X | X | SCD: learning and memory (delayed recall) | ||||||||||||
Kesse-Guyot 2012 [50] (3088; 46%)** | 45–60 | A | C (~13) | ~58–73 | ~13 | X | WM | WM | WM | WM | X | X | X | X | GCF: Average of T-scores on 6 tests (executive function; learning & memory; language) | |||||||||||
Kitamura 2017 [51] (1814; 60%)** | 44–79 | A | C (~3) | ~47–82 | ~3 | X | X | X | X | X | GCF: cognitive impairment (MMSE <24) | |||||||||||||||
Lang 2007 [52] (13,333; 57%) | ≥ 65 | A | C (~4) | ≥ 69 | ~4 | X | X | X | X | X | GCF: Binary “poor function” (bottom quintile for sum of scores on 3 tests) | |||||||||||||||
McGuire 2007 [53] (2572; 66%) critical RoB | ≥ 70 (mean 76) | A | A, C (~2) | C (~2) | ~80 | ~2 | X | X | X | X | GCF: Binary “low” or “high” (based on cut-off score on 2 tests) | |||||||||||||||
Piumatti 2018 [54] (13,342; 55%) | 40–73 | A, C | C (~5) | ~45–78 | ~5 | continuous variable | X | SCD: complex attention (mean reaction time over 7 test trials) | ||||||||||||||||||
Richard 2017 [55] (1334; 54%)** | 55–84 | A | C (~4) | C (~4) | C (~4) | C (~4) | C (~4) | C† (~4) | 85 | 14±8 (med-ian) | X | W | M | W | M | W | M | X | GCF: Binary “impaired” or “healthy” based on cut-off on Z-scores (age, sex, education adjusted MMSE) | |||||||
Sabia 2011 [56] (4073; 0%)** | ~45–55 | A | A (1) | A (1) | A (1) | A (1) | A (1) | A (T6-9), C (T10, 11) | ~55–65 | 1 | M | M | M | M | M | X | SCD: complex attention (digit symbol substitution test) | |||||||||
Sabia 2014 [57] (7153; 29%)** | 35–55 | A | A (~5) | A, C (~5) | C (~5) | C (~5) | 55–80 | ~10 | X | W M | W | W M | M | X | X | X | GCF: Average of Z-scores on 4 tests (executive function; learning & memory) | |||||||||
Samieri 2013 [58] (6174; 100%) | ≥ 60 | A | C(5.6) | C(~2) | C(~2) | ~79 (mean) | ~10 | X | X | X | X | X | GCF: Average of Z-scores on 5 tests (TICS, learning & memory, language) | |||||||||||||
Solfrizzi 2007 [59] (1445; 44%) | 65–84 | A, C | C | ~68–87 | 3.5 | X | X | X | X | X | MCI: hazard ratio for incident MCI (Petersen diagnostic criteria) | |||||||||||||||
Stott 2008 [60] (5,804; 52%)** | 70–82 | A, C | C (~1) | C (~1) | C (~1) | C (~1) | ~73–85 | 3.2 | X | X | M | X | X | X | GCF: MMSE score | |||||||||||
Wardzala 2018 [61] (486; 75%) | ≥ 80 | A, C | C (~1) | C (~1) | C (~1) | C (~1) | C (~1) | C (~1) | ~86–91 | ~5–7 | X | W M | W M | X | X | X | X | X | GCF: MMSE score (change over time) |