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Fig. 1 | Systematic Reviews

Fig. 1

From: Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol

Fig. 1

Overview of extracellular vesicles derived from mesenchymal stromal cells. Size, biogenesis, protein markers, and vesicular cargo for both exosomes and microvesicles are described. Potential mechanisms by which extracellular vesicles communicate with target cells include receptor-mediated interactions, cellular endocytosis, direct fusion with cellular membrane, and indirect interactions such as immune modulation, reactive oxygen species production, and coagulation. MVB, multivesicular body; TSG101, tumor susceptibility gene 101; ROS, reactive oxygen species

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