Induction mechanism | Model (species/strains) |
---|---|
Chemically | Â |
 i. Streptozotocin | n-STZ, NAD-STZ, STZ-S |
 ii. Alloxan | Rats, mice, non-primates |
 iii. Goldthioglucose | Obese diabetic mouse |
Genetically | Â |
 i. Obese (monogenic) | Lepob/ob mice, Leprdb/db mice, Zucker diabetic fatty rats |
 ii. Obese (polygenic) | KK mice, NZO mice, TallyHo/Jng mice NoncNZO10/LtJ mice, TSOD, OLETF rat |
 iii. Beta cell dysfunction | hIAPP mice, AKITA mice |
 iv. Spontaneously | Obese rhesus monkey (Macaca mullata) |
 v. Non-obese (polygenic) | Goto–Kakizaki rats |
Obese | Â |
 High-fat feeding | C57BL/6J mice, Desert gerbil (Psammomys obesus), Nile grass rat (Arvicanthis niloticus), Wistar Albino rats |
Surgically | Â |
 Partial pancreatectomy in animals | Rabbits, diabetic dog model |