Domain | Data items |
---|---|
Study characteristics | Study ID, year of publication, the country where the study conducted, sponsorship (funding source) |
Study population | Animal species, strain, age, gender, weight, and co-morbidities |
T2DM models | Chemical, genetic, surgical, high-fat diet |
Intervention and comparison | Taxonomical assessment (scientific name, family, identification of specimen, voucher specimen number), source, part used, description of the preparation, quality control measures, dosage, time of administration, route of administration, and duration of administration |
Outcome measures | FPG, HbA1c, IGT, HOMA-IR, HOMA-B, serum insulin concentration, whole pancreas insulin content, morphometrics of pancreases, FFAs, TGs, TC, HDL cholesterol, LDL cholesterol, liver glycogen, ALT, AST, ALP, GGT, urea, BUN, serum creatinine, total protein, albumin, globulin, bilirubin total, calcium, phosphorus, death, Hb, packed cell volume, total red blood cells, total white blood cells, differential white cell counts, platelet count, and absolute red blood cell indices. |
Risk of bias assessment and quality of reporting of preclinical study | Baseline data (weight, microbiological status, age, drug- or test-naïve), Sequence generation, allocation concealment, random housing, blinding of investigators/caregivers, random outcome assessment, blinding of the assessor, incomplete outcome data, selective outcome reporting and other source of bias, blinded assessment of outcome, publication after peer review, statement of temperature control, appropriate animal model (aged, diabetic mellitus, type 2), sample size calculation, compliance with animal welfare regulations, statement of potential conflict of interests |