First author (year) | Specimen type (No. of specimens CRC/C) | F. nucleatum quantification measures reported | Statistics reported | F. nucleatum load in CRC compared to C | ||
---|---|---|---|---|---|---|
C | CRC | p | ||||
Relative abundance | ||||||
 Zhang (2018) [42] | Feces (130/130) | Relative contribution to total bacteria (%) | Mean | 0.001 | 0.17 | < 0.001 |
 Vogtmann (2016) [53] | Feces (52/53) | Relative contribution to total bacteria (%) | Mean | 0.003 | 0.08 | 0.043 |
 Wang (2012) [55] | Feces (46/56) | Relative contribution to total bacteria (%) | Mean | 0.002 | 0.061 | 0.005 |
Absolute quantification | ||||||
 Yu (2017) [60] | Feces (74/54) | Bacteria counts | Rank mean | 45.09 IMG 40.32 MLG 54.62 OTU | 78.66 IMG 82.14 MLG 71.71 OTU | < 0.001 |
 Suehiro (2017) [45] | Feces (158/60) | Absolute copy number of F. nucleatum | Median (min–max) | 17.5 (0–5793) | 317 (0–17,343) | < 0.0001 |
 Fukugaiti (2015) [44] | Feces (7/10) | Log no. copies of F. nucleatum/gram | Mean ± SD (min-max) | 4.0 ± 1.5 (1.0–6.4) | 6.2 ± 1.5 (3.5–8.0) | 0.01 |
 Mira-Pascual (2015) [50] | Feces (6/10) | Log no. gene copies of F. nucleatum/mg | Median (IQR) | 4.16 (3.47–4.85) | 4.70 (3.85–5.15) | --- |
 Rezasoltani (2018) [46] | Feces (20/31) | Cq value (Quantity of F. nucleatum = 10 (\( \frac{Cq-b}{m} \) )) | Mean (SD) | 29.16 (3.31) | 17.74 (3.59) | < 0.05 |
 Liu (2020) [62] | Feces (53/45) | Log 10 copies of F. nucleatum ∕ gram | Mean (SD) | ≈3.5 (1) | ≈6 (1) | < 0.01 |
Relative quantification | ||||||
 Russo (2017) [52] | Feces (10/10) | Ratio: \( \frac{Cq\kern0.5em F. nucleatum\kern0.75em }{Cq\ total\ bacteria} \) | Mean | ≈2.25 | ≈1.8 | > 0.05 |
 Yu (2015) [41] | Feces (42/52) | ΔCq value | Median [IQR] | ≈26 [2] | ≈19 [2] | < 0.001 |
Biopsy (31/37) | ≈27 [2] | ≈18 [3] | < 0.001 | |||
 Flanagan (2014) [43] | Feces (7 /25) | 2−ΔCq value | Median | 2−21 | 2−15 | 0.02 |
 Liang (2017) [49] Coh I | Feces (170/200) | 2−ΔCq value | Median | ≈2−17 | ≈2−5 | < 0.0001 |
 Liang (2017) [49] Coh II | Feces (33/36) | 2−ΔCq value | Median | ≈2−16 | ≈2−13 | 0.012 |
 Eklof (2017) [47] | Feces (39/66) | Log 2−ΔCq | Median [IQR] | ≈− 10 [2] | ≈− 7 [5] | < 0.001 |
 Guo (2018) [48] | Feces (215/156) | Log 2−ΔCq | Mean | ≈−4 | ≈− 3 | < 0.0001 |
 Wong (2017) [56] | Feces (104/102) | Log 2−ΔCq (fold change from HC to CRC) | Mean | ≈−7 | ≈−5 (132) | < 0.001 |
 Xie (2017) [58] | Feces (327/242) | Log2 RQ, based on ΔCq (Fold change from HC to CRC) | Mean | ≈−20 | ≈− 16 for early stage and −18 for advanced stage (5.12) | 0.006 < 0.001 |
 Tunsjo (2019) [61] | Feces (23/22) | 2−ΔCq value (fold change from HC to CRC) | Median | ≈2−7 | ≈2−5 (66) | 0.0073 |