Table 2 Data extraction variables

Study inclusion/exclusion

If excluded, rationale provided

Design and setting

Dates

Study duration

N, number of groups, and dropout rates

Participant demographics

This will include baseline cognitive status and activity or fitness level, diagnosis, disease severity, co-morbidities, Apo-E status, age, sex, nationality and/or ethnicity, socioeconomic status, and education

Included caregiver or caretaker

Recruitment approach

Adherence reported according to how intervention was recorded

For example, supervised, unsupervised, objective monitors, etc.

Follow-up assessment

Outcomes

To include cognitive, emotional, functional, motor, physiological, social, or quality of life

Reported challenges and conflicts

Bias assessment variables

To include randomization method, randomization concealment, blinding, method of reporting outcomes, missing information, and other relevant variables

Outcome description

To include scale range; minimal detectable change; and/or minimal clinically important difference; incidence of dementia; time to conversion; changes in health, cognitive, or quality of life variables; and changes in dementia related biomarkers

Other outcome factors

To include time to follow-up in study methodology, scale range, minimal detectable change, and/or minimal clinically important difference

Results: included participant group sizes, summary of results

For example, means, SD, and statistical changes

 Physical activity/exercise modality

For example, type, group, peer/coach, and additional motivators

 Treatment minutes/session

 Treatment duration

Total number of weeks

 Supervised or unsupervised treatment paradigm

 Harm or side effects

Drug or secondary health condition interaction