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  1. Antidepressant medicines are used to manage symptoms of low back pain. The efficacy, acceptability, and safety of antidepressant medicines for low back pain (LBP) are not clear. We aimed to evaluate the effica...

    Authors: Michael C. Ferraro, Matthew K. Bagg, Michael A. Wewege, Aidan G. Cashin, Hayley B. Leake, Rodrigo R. N. Rizzo, Matthew D. Jones, Sylvia M. Gustin, Richard Day, Colleen K. Loo and James H. McAuley

    Citation: Systematic Reviews 2021 10:62

    Content type: Research

    Published on:

  2. Health practitioners and researchers must be able to measure and assess maternal care quality in facilities to monitor, intervene, and reduce global maternal mortality rates. On the global scale, there is a ge...

    Authors: Kyrah K. Brown, Godfred O. Boateng, Peace Ossom-Williamson and Laura Haygood

    Citation: Systematic Reviews 2021 10:61

    Content type: Protocol

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  3. Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the l...

    Authors: Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub and Suzan Haidar

    Citation: Systematic Reviews 2021 10:60

    Content type: Systematic review update

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  4. Globally, very preterm birth is a health concern leading to various developmental difficulties such as poor motor and/or cognitive function. For infants born very preterm, family-centered care (FCC) might prom...

    Authors: Manasa Kolibylu Raghupathy, Bhamini Krishna Rao, Shubha R. Nayak, Alicia J. Spittle and Shradha S. Parsekar

    Citation: Systematic Reviews 2021 10:59

    Content type: Protocol

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  5. The relationship between cancer with overweight and obesity has been extensively reported. However, the association between urinary cancers with these risk factors remains unclear, with existing reports showin...

    Authors: Jiyuan Shi, Liang Zhao, Ya Gao, Mingming Niu, Meili Yan, Yamin Chen, Ziwei Song, Xueni Ma, Peng Wang and Jinhui Tian

    Citation: Systematic Reviews 2021 10:58

    Content type: Research

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  6. Obstructed labor accounted for 22% of obstetrical complications and 9% of all maternal deaths in low- and middle-income countries. Even though there are separate studies regarding obstructed labor and its comp...

    Authors: Yordanos Gizachew Yeshitila, Melaku Desta and Abraham Kebede

    Citation: Systematic Reviews 2021 10:57

    Content type: Protocol

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  7. High tibial osteotomy (HTO) has been used for over 60 years in clinical practice and mainly comprises two major techniques: closed wedge high tibial osteotomy (CWHTO) and open wedge high tibial osteotomy (OWHT...

    Authors: Mingliang He, Xihong Zhong, Zhong Li, Kun Shen and Wen Zeng

    Citation: Systematic Reviews 2021 10:56

    Content type: Systematic review update

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  8. The scale-up of evidence-based innovations is required to reduce waste and inequities in health and social services (HSS). However, it often tends to be a top-down process initiated by policy makers, and the v...

    Authors: Ali Ben Charif, Karine V. Plourde, Sabrina Guay-Bélanger, Hervé Tchala Vignon Zomahoun, Amédé Gogovor, Sharon Straus, Ron Beleno, Kathy Kastner, Robert K. D. McLean, Andrew J. Milat, Luke Wolfenden, Jean-Sébastien Paquette, Friedemann Geiger and France Légaré

    Citation: Systematic Reviews 2021 10:55

    Content type: Protocol

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  9. People living with human immunodeficiency virus (PLHIV) struggle with the challenges of living with a chronic disease and integrating antiretroviral treatment (ART) and care into their daily lives. The aims of...

    Authors: Lynn Hendricks, Ingrid Eshun-Wilson and Anke Rohwer

    Citation: Systematic Reviews 2021 10:54

    Content type: Methodology

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  10. Chronic pain is a common public health problem with negative consequences for individuals and societies. Fortunately, interdisciplinary chronic pain management has been shown to be effective for improving pati...

    Authors: Hervé Tchala Vignon Zomahoun, Regina Visca, Nicole George and Sara Ahmed

    Citation: Systematic Reviews 2021 10:53

    Content type: Protocol

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  11. Physical inactivity is one of the major risk factors for non-communicable diseases. This systematic review and meta-analysis aimed to assess the effects of educational interventions on promoting regular physic...

    Authors: Babak Moeini, Forouzan Rezapur-Shahkolai, Saeed Bashirian, Amin Doosti-Irani, Maryam Afshari and Azam Geravandi

    Citation: Systematic Reviews 2021 10:52

    Content type: Systematic review update

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  12. Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, deve...

    Authors: Marcela Larissa Costa, Carlos Adriano Santos Souza, Ana Caroline Cardoso Silva, Dayane Franciely Conceição Santos, Edilene Fernandes Nonato, Francismayne Batista Santana, Giselle dos Santos Dias, Jessyca Teles Barreto, Laís Santos Costa, Maria Carolina Barros Costa, Tamila das Neves Ferreira, Jeniffer Santos Santana, Raquel Simões Mendes-Netto, Tereza Virgínia Silva Bezerra do Nascimento, Marco Antônio Prado Nunes and Márcia Ferreira Cândido de Souza

    Citation: Systematic Reviews 2021 10:51

    Content type: Protocol

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  13. Depression is one of the most prevalent mental disorders among an estimated 25.6 million people living with HIV (PLHIV) in sub-Saharan Africa (SSA). The depression rate is higher in HIV-seropositive men who ha...

    Authors: Delarise M. Mulqueeny, Senzelokuhle M. Nkabini and Manduleli H. Pokiya

    Citation: Systematic Reviews 2021 10:50

    Content type: Protocol

    Published on:

  14. Psychosocial health issues such as depression and social isolation are an important cause of morbidity and premature mortality for older adults and people with dementia. Social robots are promising technologic...

    Authors: Wei Qi Koh, Simone Anna Felding, Elaine Toomey and Dympna Casey

    Citation: Systematic Reviews 2021 10:49

    Content type: Protocol

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  15. The COVID-19 pandemic is creating severe issues for healthcare and broad social structures, exposing societal vulnerabilities. Among the populations affected by COVID-19 are people engaged in substance use, su...

    Authors: Navin Kumar, Kamila Janmohamed, Kate Nyhan, Silvia S. Martins, Magdalena Cerda, Deborah Hasin, Jenny Scott, Richard Pates, Lilian Ghandour, Mayyada Wazaify and Kaveh Khoshnood

    Citation: Systematic Reviews 2021 10:48

    Content type: Protocol

    Published on:

  16. More than 75% of patients presenting to the Emergency Department are suffering symptoms of pain. Despite this, 67% will not receive any analgesia. Methoxyflurane is a fluorinated hydrocarbon gas which has anal...

    Authors: Michael M. Eager, Grant S. Nolan, Kathryn Tonks, Anoopama Ramjeeawon and Natalie Taylor

    Citation: Systematic Reviews 2021 10:47

    Content type: Protocol

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  17. Of the 15–20% of youth in North America affected by a chronic health condition (e.g., type 1 diabetes, cystic fibrosis) and/or mental health or neurodevelopmental disorder (e.g., depression, eating disorder, A...

    Authors: Kyleigh Schraeder, Brooke Allemang, Cathie Scott, Kerry McBrien, Gina Dimitropoulos, Ashley Felske and Susan Samuel

    Citation: Systematic Reviews 2021 10:46

    Content type: Protocol

    Published on:

  18. Dental and oral health workers have direct contact with respiratory aerosols of patients during procedures. This study aimed to determine the main concerns of dental and oral health workers globally during COV...

    Authors: Peivand Bastani, Mohammadtaghi Mohammadpour, Arash Ghanbarzadegan, Kostas Kapellas and Loc Giang Do

    Citation: Systematic Reviews 2021 10:45

    Content type: Research

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  19. In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health ca...

    Authors: Sarah Elliott, Alexandra Berlangieri, Jason Wasiak, Michael Chao and Farshad Foroudi

    Citation: Systematic Reviews 2021 10:44

    Content type: Protocol

    Published on:

  20. Cancer patients are particularly vulnerable to COVID-19, partially owing to their compromised immune systems and curbed or cut cancer healthcare services caused by the pandemic. As a result, cancer caregivers ...

    Authors: Zhaohui Su, Dean McDonnell, Bin Liang, Jennifer Kue, Xiaoshan Li, Sabina Šegalo, Shailesh Advani, Bertha E. Flores and Jing Wang

    Citation: Systematic Reviews 2021 10:43

    Content type: Protocol

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  21. Healthcare settings are complex, and the decision-making process is usually complicated, too. Precise use of best evidence from different sources for increasing the desired outcomes is the result of EBM. There...

    Authors: Tahereh Shafaghat, Mohammad Hasan Imani Nasab, Mohammad Amin Bahrami, Zahra Kavosi, Mahsa Roozrokh Arshadi Montazer, Mohammad Kazem Rahimi Zarchi and Peivand Bastani

    Citation: Systematic Reviews 2021 10:42

    Content type: Research

    Published on:

  22. Mental health problems are common in the working population and represent a growing concern internationally, with potential impacts on workers, organisations, workplace health and compensation authorities, lab...

    Authors: Charlotte Paterson, Caleb Leduc, Margaret Maxwell, Birgit Aust, Benedikt L. Amann, Arlinda Cerga-Pashoja, Evelien Coppens, Chrisje Couwenbergh, Cliodhna O’Connor, Ella Arensman and Birgit A. Greiner

    Citation: Systematic Reviews 2021 10:41

    Content type: Protocol

    Published on:

  23. Inflammation scores based on general inflammation markers as leucocyte count or C-reactive protein have been evaluated as prognostic markers of inferior survival in several cancers. In small cell lung cancer (...

    Authors: Anne Winther-Larsen, Ninna Aggerholm-Pedersen and Birgitte Sandfeld-Paulsen

    Citation: Systematic Reviews 2021 10:40

    Content type: Research

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  24. Literature searches underlie the foundations of systematic reviews and related review types. Yet, the literature searching component of systematic reviews and related review types is often poorly reported. Gui...

    Authors: Melissa L. Rethlefsen, Shona Kirtley, Siw Waffenschmidt, Ana Patricia Ayala, David Moher, Matthew J. Page and Jonathan B. Koffel

    Citation: Systematic Reviews 2021 10:39

    Content type: Research

    Published on:

  25. Systematic reviews involve searching multiple bibliographic databases to identify eligible studies. As this type of evidence synthesis is increasingly pursued, the use of various electronic platforms can help ...

    Authors: Sandra McKeown and Zuhaib M. Mir

    Citation: Systematic Reviews 2021 10:38

    Content type: Methodology

    Published on:

  26. Global responses to the COVID-19 pandemic have exposed and exacerbated existing socioeconomic and health inequities that disproportionately affect the sexual health and well-being of many populations, includin...

    Authors: Navin Kumar, Kamila Janmohamed, Kate Nyhan, Laura Forastiere, Wei-Hong Zhang, Anna Kågesten, Maximiliane Uhlich, Sarah M. Van de Velde, Joel M. Francis, Jennifer T. Erausquin, Elin C. Larsson, Denton Callander, John Scott, Victor Minichiello and Joseph D. Tucker

    Citation: Systematic Reviews 2021 10:37

    Content type: Protocol

    Published on:

  27. Preoperative anemia is a common comorbidity that often necessitates allogeneic blood transfusion (ABT). As there is a risk associated with blood transfusions, preoperative intravenous iron (IV) has been propos...

    Authors: Abdelsalam M. Elhenawy, Steven R. Meyer, Sean M. Bagshaw, Roderick G. MacArthur and Linda J. Carroll

    Citation: Systematic Reviews 2021 10:36

    Content type: Research

    Published on:

  28. Chimeric antigen receptor (CAR) T cell therapy has had great success in treating patients with relapsed or refractory B cell malignancies, with CD19-targeting therapies now approved in many countries. However,...

    Authors: Komal Adeel, Nathan J. Fergusson, Risa Shorr, Harold Atkins and Kevin A. Hay

    Citation: Systematic Reviews 2021 10:35

    Content type: Protocol

    Published on:

  29. All individuals should have the right to engage meaningfully in occupations that meet their aspirations and life goals as well as promote their health and well-being. For individuals with disability, meaningfu...

    Authors: Jacqueline Nhu Quynh Pho, Aidan Christopher Tan, Katrina Chaudhary, Sonia Hines, Caroline Ellison, Vivian Isaac and David Lim

    Citation: Systematic Reviews 2021 10:34

    Content type: Protocol

    Published on:

  30. A variety of public health interventions have been undertaken in low- and middle-income countries (LMICs) to prevent morbidity and mortality associated with household air pollution (HAP) due to cooking, heatin...

    Authors: Katherine E. Woolley, Emma Dickinson-Craig, Suzanne E. Bartington, Tosin Oludotun, Bruce Kirenga, Shelton T. Mariga, Telesphore Kabera, April Coombe, Francis D. Pope, Ajit Singh, William R. Avis, Rosie Day, David Warburton, Semira Manaseki-Holland, David J. Moore and G. Neil Thomas

    Citation: Systematic Reviews 2021 10:33

    Content type: Protocol

    Published on:

  31. Progressive language difficulties arise in many neurodegenerative conditions, causing significant impact upon patients and families. This occurs most obviously in primary progressive aphasia (PPA) but can also...

    Authors: Sharon A. Savage, Aida Suárez-González, Alice Cassani, Ragaviveka Gopalan and Joshua Stott

    Citation: Systematic Reviews 2021 10:32

    Content type: Protocol

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  32. Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be v...

    Authors: Fereshteh Ghahvechi Khaligh, Abbas Jafari, Elena Silivanova, Mikhail Levchenko, Bahlol Rahimi and Saber Gholizadeh

    Citation: Systematic Reviews 2021 10:30

    Content type: Systematic review update

    Published on:

  33. Despite the extensive research that has been conducted to date, practice often differs from established guidelines and will vary between individuals and organisations. It has been noted that the global uptake ...

    Authors: Sarah Hassan, Vincent Chan, Julie Stevens and Ieva Stupans

    Citation: Systematic Reviews 2021 10:29

    Content type: Research

    Published on:

  34. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. To decrease the high case fatality rates and morbidity for sepsis and septic shock, there is a need to increa...

    Authors: Ivana Pepic, Robert Feldt, Lars Ljungström, Richard Torkar, Daniel Dalevi, Hanna Maurin Söderholm, Lars-Magnus Andersson, Marina Axelson-Fisk, Katarina Bohm, Bengt Arne Sjöqvist and Stefan Candefjord

    Citation: Systematic Reviews 2021 10:28

    Content type: Protocol

    Published on:

  35. Vision loss due to diabetic retinopathy can largely be prevented or delayed through treatment. Patients with vision-threatening diabetic retinopathy are typically offered laser or intravitreal injections which...

    Authors: Covadonga Bascaran, Nyawira Mwangi, Fabrizio D’Esposito, Charles Cleland, Iris Gordon, Juan Alberto Lopez Ulloa, Ranad Maswadi, Shaffi Mdala, Jacqueline Ramke, Jennifer R. Evans and Matthew Burton

    Citation: Systematic Reviews 2021 10:27

    Content type: Protocol

    Published on:

  36. Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. Howeve...

    Authors: Shuang Jiang, Meng-meng Zhou, Rong Xia, Jing-hui Bai and Li-hui Yan

    Citation: Systematic Reviews 2021 10:26

    Content type: Protocol

    Published on:

  37. Telephone-based digital triage is widely used by services that provide urgent care. This involves a call handler or clinician using a digital triage tool to generate algorithm-based care advice, based on a pat...

    Authors: Vanashree Sexton, Jeremy Dale and Helen Atherton

    Citation: Systematic Reviews 2021 10:25

    Content type: Protocol

    Published on:

  38. Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marke...

    Authors: Andrew Beck, John C. LeBlanc, Kate Morissette, Candyce Hamel, Becky Skidmore, Heather Colquhoun, Eddy Lang, Ainsley Moore, John J. Riva, Brett D. Thombs, Scott Patten, Heather Bragg, Ian Colman, Gary S. Goldfield, Stuart Gordon Nicholls, Kathleen Pajer…

    Citation: Systematic Reviews 2021 10:24

    Content type: Protocol

    Published on:

  39. Structural stigma in health systems experienced by consumers diagnosed with Borderline Personality Disorder (BPD) is a widespread phenomenon that causes major health inequities and harm for this population. St...

    Authors: Pauline Klein, Alicia Kate Fairweather, Sharon Lawn, Helen Margaret Stallman and Paul Cammell

    Citation: Systematic Reviews 2021 10:23

    Content type: Protocol

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  40. Cardiac surgery is becoming increasingly common in older, more vulnerable adults. A focus on timely and complete medical and functional recovery has led to the development of enhanced recovery protocols (ERPs)...

    Authors: Nebojša Oravec, Rakesh C. Arora, Brian Bjorklund, April Gregora, Caroline Monnin, Todd A. Duhamel, David E. Kent, Annette S. H. Schultz and Anna M. Chudyk

    Citation: Systematic Reviews 2021 10:22

    Content type: Protocol

    Published on:

  41. Sexual risk, substance use, and mental ill health constitute a syndemic of co-occurring, mutually reinforcing epidemics amongst men who have sex with men (MSM). Developed since 1995, e-health interventions off...

    Authors: Rebecca Meiksin, G. J. Melendez-Torres, Jane Falconer, T. Charles Witzel, Peter Weatherburn and Chris Bonell

    Citation: Systematic Reviews 2021 10:21

    Content type: Research

    Published on:

  42. Chronic obstructive pulmonary disease (COPD) is increasingly contributing to the disease burden in South Asia. This review will summarize the prevalence and risk factors of COPD in South Asia and the intervent...

    Authors: Rafiqul Islam, Md. Tarek Hossain, Nantu Chakma, Afroza Khanom, Tapas Mazumder and Md. Tauhidul Islam

    Citation: Systematic Reviews 2021 10:20

    Content type: Protocol

    Published on:

  43. Culture influences nurses’ attitudes towards caring for older adults. Additionally, nursing students’ perceptions and attitudes towards older adults affect their behavior, possibly their career choices and/or ...

    Authors: Esther L. Wanko Keutchafo, Jane Kerr, Mary A. Jarvis and Desmond Kuupiel

    Citation: Systematic Reviews 2021 10:19

    Content type: Protocol

    Published on:

  44. An estimated 20–30% of community-dwelling Canadian adults aged 65 years or older experience one or more falls each year. Fall-related injuries are a leading cause of hospitalization and can lead to functional ...

    Authors: Jennifer Pillay, John J. Riva, Laure A. Tessier, Heather Colquhoun, Eddy Lang, Ainsley E. Moore, Brett D. Thombs, Brenda J. Wilson, Amanda Tzenov, Catherine Donnelly, Marcel Émond, Jayna Holroyd-Leduc, Jamie Milligan, Diana Keto-Lambert, Sholeh Rahman, Ben Vandermeer…

    Citation: Systematic Reviews 2021 10:18

    Content type: Protocol

    Published on:

  45. The purpose of this study was to comprehensively assess the heterogeneity of procedures in the diagnostic guidelines for acute pancreatitis and to identify gaps limiting knowledge in diagnosing this disease.

    Authors: Ke-Qian Yi, Ting Yang, Yan-Min Yang, Guo-Li Lan, Li-Ya An, Yu-Xing Qi, Hong-Bo Fan, Yong-Qing Duan and Da-Li Sun

    Citation: Systematic Reviews 2021 10:17

    Content type: Research

    Published on:

  46. The increasingly rapid rate of evidence publication has made it difficult for evidence synthesis—systematic reviews and health guidelines—to be continually kept up to date. One proposed solution for this is th...

    Authors: Anneliese Arno, Julian Elliott, Byron Wallace, Tari Turner and James Thomas

    Citation: Systematic Reviews 2021 10:16

    Content type: Research

    Published on:

  47. Sexual orientation and gender identity and expression change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or...

    Authors: David J. Kinitz, Travis Salway, Elisabeth Dromer, Dean Giustini, Florence Ashley, Trevor Goodyear, Olivier Ferlatte, Hannah Kia and Alex Abramovich

    Citation: Systematic Reviews 2021 10:14

    Content type: Protocol

    Published on:

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