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  1. Despite the extensive research that has been conducted to date, practice often differs from established guidelines and will vary between individuals and organisations. It has been noted that the global uptake ...

    Authors: Sarah Hassan, Vincent Chan, Julie Stevens and Ieva Stupans

    Citation: Systematic Reviews 2021 10:29

    Content type: Research

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  2. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. To decrease the high case fatality rates and morbidity for sepsis and septic shock, there is a need to increa...

    Authors: Ivana Pepic, Robert Feldt, Lars Ljungström, Richard Torkar, Daniel Dalevi, Hanna Maurin Söderholm, Lars-Magnus Andersson, Marina Axelson-Fisk, Katarina Bohm, Bengt Arne Sjöqvist and Stefan Candefjord

    Citation: Systematic Reviews 2021 10:28

    Content type: Protocol

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  3. Vision loss due to diabetic retinopathy can largely be prevented or delayed through treatment. Patients with vision-threatening diabetic retinopathy are typically offered laser or intravitreal injections which...

    Authors: Covadonga Bascaran, Nyawira Mwangi, Fabrizio D’Esposito, Charles Cleland, Iris Gordon, Juan Alberto Lopez Ulloa, Ranad Maswadi, Shaffi Mdala, Jacqueline Ramke, Jennifer R. Evans and Matthew Burton

    Citation: Systematic Reviews 2021 10:27

    Content type: Protocol

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  4. Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. Howeve...

    Authors: Shuang Jiang, Meng-meng Zhou, Rong Xia, Jing-hui Bai and Li-hui Yan

    Citation: Systematic Reviews 2021 10:26

    Content type: Protocol

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  5. Telephone-based digital triage is widely used by services that provide urgent care. This involves a call handler or clinician using a digital triage tool to generate algorithm-based care advice, based on a pat...

    Authors: Vanashree Sexton, Jeremy Dale and Helen Atherton

    Citation: Systematic Reviews 2021 10:25

    Content type: Protocol

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  6. Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marke...

    Authors: Andrew Beck, John C. LeBlanc, Kate Morissette, Candyce Hamel, Becky Skidmore, Heather Colquhoun, Eddy Lang, Ainsley Moore, John J. Riva, Brett D. Thombs, Scott Patten, Heather Bragg, Ian Colman, Gary S. Goldfield, Stuart Gordon Nicholls, Kathleen Pajer…

    Citation: Systematic Reviews 2021 10:24

    Content type: Protocol

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  7. Structural stigma in health systems experienced by consumers diagnosed with Borderline Personality Disorder (BPD) is a widespread phenomenon that causes major health inequities and harm for this population. St...

    Authors: Pauline Klein, Alicia Kate Fairweather, Sharon Lawn, Helen Margaret Stallman and Paul Cammell

    Citation: Systematic Reviews 2021 10:23

    Content type: Protocol

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  8. Cardiac surgery is becoming increasingly common in older, more vulnerable adults. A focus on timely and complete medical and functional recovery has led to the development of enhanced recovery protocols (ERPs)...

    Authors: Nebojša Oravec, Rakesh C. Arora, Brian Bjorklund, April Gregora, Caroline Monnin, Todd A. Duhamel, David E. Kent, Annette S. H. Schultz and Anna M. Chudyk

    Citation: Systematic Reviews 2021 10:22

    Content type: Protocol

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  9. Sexual risk, substance use, and mental ill health constitute a syndemic of co-occurring, mutually reinforcing epidemics amongst men who have sex with men (MSM). Developed since 1995, e-health interventions off...

    Authors: Rebecca Meiksin, G. J. Melendez-Torres, Jane Falconer, T. Charles Witzel, Peter Weatherburn and Chris Bonell

    Citation: Systematic Reviews 2021 10:21

    Content type: Research

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  10. Chronic obstructive pulmonary disease (COPD) is increasingly contributing to the disease burden in South Asia. This review will summarize the prevalence and risk factors of COPD in South Asia and the intervent...

    Authors: Rafiqul Islam, Md. Tarek Hossain, Nantu Chakma, Afroza Khanom, Tapas Mazumder and Md. Tauhidul Islam

    Citation: Systematic Reviews 2021 10:20

    Content type: Protocol

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  11. Culture influences nurses’ attitudes towards caring for older adults. Additionally, nursing students’ perceptions and attitudes towards older adults affect their behavior, possibly their career choices and/or ...

    Authors: Esther L. Wanko Keutchafo, Jane Kerr, Mary A. Jarvis and Desmond Kuupiel

    Citation: Systematic Reviews 2021 10:19

    Content type: Protocol

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  12. An estimated 20–30% of community-dwelling Canadian adults aged 65 years or older experience one or more falls each year. Fall-related injuries are a leading cause of hospitalization and can lead to functional ...

    Authors: Jennifer Pillay, John J. Riva, Laure A. Tessier, Heather Colquhoun, Eddy Lang, Ainsley E. Moore, Brett D. Thombs, Brenda J. Wilson, Amanda Tzenov, Catherine Donnelly, Marcel Émond, Jayna Holroyd-Leduc, Jamie Milligan, Diana Keto-Lambert, Sholeh Rahman, Ben Vandermeer…

    Citation: Systematic Reviews 2021 10:18

    Content type: Protocol

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  13. The purpose of this study was to comprehensively assess the heterogeneity of procedures in the diagnostic guidelines for acute pancreatitis and to identify gaps limiting knowledge in diagnosing this disease.

    Authors: Ke-Qian Yi, Ting Yang, Yan-Min Yang, Guo-Li Lan, Li-Ya An, Yu-Xing Qi, Hong-Bo Fan, Yong-Qing Duan and Da-Li Sun

    Citation: Systematic Reviews 2021 10:17

    Content type: Research

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  14. The increasingly rapid rate of evidence publication has made it difficult for evidence synthesis—systematic reviews and health guidelines—to be continually kept up to date. One proposed solution for this is th...

    Authors: Anneliese Arno, Julian Elliott, Byron Wallace, Tari Turner and James Thomas

    Citation: Systematic Reviews 2021 10:16

    Content type: Research

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  15. Sexual orientation and gender identity and expression change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or...

    Authors: David J. Kinitz, Travis Salway, Elisabeth Dromer, Dean Giustini, Florence Ashley, Trevor Goodyear, Olivier Ferlatte, Hannah Kia and Alex Abramovich

    Citation: Systematic Reviews 2021 10:14

    Content type: Protocol

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  16. Knowledge translation (KT) theories, frameworks, and models (TFMs) can help guide and explain KT processes, and facilitate the evaluation of implementation outcomes. They play a critical role in conducting KT ...

    Authors: Junqiang Zhao, Xuejing Li, Lijiao Yan, Yamei Yu, Jiale Hu, Shelly-Anne Li and Wenjun Chen

    Citation: Systematic Reviews 2021 10:13

    Content type: Protocol

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  17. Existing self-management and behavioural interventions for diabetes vary widely in their content, and their sustained long-term effectiveness is uncertain. Autonomy supporting interventions may be a prerequisi...

    Authors: Anne Sophie Mathiesen, Mette Juel Rothmann, Vibeke Zoffmann, Janus Christian Jakobsen, Christian Gluud, Jane Lindschou, Mette Due-Christensen, Bodil Rasmussen, Emilie Marqvorsen and Thordis Thomsen

    Citation: Systematic Reviews 2021 10:12

    Content type: Protocol

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  18. Cost-related nonadherence to medications (CRNA) is common in many countries and thought to be associated with adverse outcomes. The characteristics of CRNA in Canada, with its patchwork coverage of increasingl...

    Authors: Anne M. Holbrook, Mei Wang, Munil Lee, Zhiyuan Chen, Michael Garcia, Laura Nguyen, Angela Ford, Selina Manji and Michael R. Law

    Citation: Systematic Reviews 2021 10:11

    Content type: Research

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  19. Symptoms in multiple sclerosis (MS) can lead to different types and ranges of sexual dysfunction in MS patients. Studies in different parts of the world have reported a high range of sexual dysfunction in men ...

    Authors: Maryam Dastoorpoor, Maryam Zamanian, Rahmatollah Moradzadeh, Seyed Massood Nabavi and Raana Kousari

    Citation: Systematic Reviews 2021 10:10

    Content type: Systematic review update

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  20. Respiratory distress syndrome (RDS) is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration. Commonly, surfactant i...

    Authors: Vincent D. Gaertner, Dirk Bassler and Christoph M. Rüegger

    Citation: Systematic Reviews 2021 10:9

    Content type: Protocol

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  21. Total hip and knee arthroplasty are a highly performed surgery; however, patient satisfaction with surgery results and patient involvement in the decision-making process remains low. Patient decision aids (PtD...

    Authors: Lissa Pacheco-Brousseau, Marylène Charette, Dawn Stacey and Stéphane Poitras

    Citation: Systematic Reviews 2021 10:8

    Content type: Protocol

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  22. Both cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis are characterized by permanent bronchial dilation, impaired mucociliary clearance, and development of chronic colonization and infection. Althou...

    Authors: Salony Verma, Joseph L. Mathew and Pallab Ray

    Citation: Systematic Reviews 2021 10:7

    Content type: Protocol

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  23. The growing societal and economic impact of Alzheimer’s disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise,...

    Authors: Julie M. Faieta, Hannes Devos, Prasanna Vaduvathiriyan, Michele K. York, Kirk I. Erickson, Mark A. Hirsch, Brian G. Downer, Erwin E. H. van Wegen, Diana C. Wong, Elena Philippou, Ahmed Negm, Pedram Ahmadnezhad, Shilpa Krishnan, Melike Kahya, Pallavi Sood and Patricia C. Heyn

    Citation: Systematic Reviews 2021 10:6

    Content type: Protocol

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  24. The antioxidant potential of vitamin C is useful in reducing oxidative stress, free radicals, and reactive oxygen species, which may assist in the improved outcomes of periodontal therapy. This systematic revi...

    Authors: Hytham N. Fageeh, Hammam I. Fageeh, Ashwin Prabhu, Shilpa Bhandi, Shahrukh Khan and Shankargouda Patil

    Citation: Systematic Reviews 2021 10:5

    Content type: Systematic review update

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  25. Diabetic retinopathy is the most common ocular complication of diabetes and a cause of vision loss in adults. Diabetic retinopathy screening leading to early identification of the disease followed by timely tr...

    Authors: Covadonga Bascaran, Nyawira Mwangi, Fabrizio D’Esposito, Iris Gordon, Juan Alberto Lopez Ulloa, Shaffi Mdala, Jacqueline Ramke, Jennifer R. Evans and Matthew Burton

    Citation: Systematic Reviews 2021 10:4

    Content type: Protocol

    Published on:

  26. Climate change is a defining issue and grand challenge for the health sector in North America. Synthesizing evidence on climate change impacts, climate-health adaptation, and climate-health mitigation is cruci...

    Authors: Sherilee L. Harper, Ashlee Cunsolo, Amreen Babujee, Shaugn Coggins, Mauricio Domínguez Aguilar and Carlee J. Wright

    Citation: Systematic Reviews 2021 10:3

    Content type: Protocol

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  27. To inform recommendations by the Canadian Task Force on Preventive Health Care on screening in primary care for the prevention and early detection of cervical cancer by systematically reviewing evidence of (a)...

    Authors: Allison Gates, Jennifer Pillay, Donna Reynolds, Rob Stirling, Gregory Traversy, Christina Korownyk, Ainsley Moore, Guylène Thériault, Brett D. Thombs, Julian Little, Catherine Popadiuk, Dirk van Niekerk, Diana Keto-Lambert, Ben Vandermeer and Lisa Hartling

    Citation: Systematic Reviews 2021 10:2

    Content type: Protocol

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  28. Population health (PH) research capacity and performance are essential pillars of evidence-based practice to help address health inequalities. Best evidence is provided by systematic reviews (SRs). None of the...

    Authors: Karima Chaabna, Sohaila Cheema, Amit Abraham, Patrick Maisonneuve, Albert B. Lowenfels and Ravinder Mamtani

    Citation: Systematic Reviews 2021 10:1

    Content type: Research

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  29. Despite existing research on text mining and machine learning for title and abstract screening, the role of machine learning within systematic literature reviews (SLRs) for health technology assessment (HTA) r...

    Authors: E. Popoff, M. Besada, J. P. Jansen, S. Cope and S. Kanters

    Citation: Systematic Reviews 2020 9:293

    Content type: Methodology

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  30. Despite the increase in the number of people accessing antiretroviral therapy (ART), there is limited data regarding treatment failure and its related factors among HIV-positive individuals enrolled in HIV car...

    Authors: Yishak Lailulo, Marcel Kitenge, Shahista Jaffer, Omololu Aluko and Peter Suwirakwenda Nyasulu

    Citation: Systematic Reviews 2020 9:292

    Content type: Research

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  31. Bone is a plastic tissue that is responsive to its physical environment. As a result, exercise interventions represent a potential means to influence the bone. However, little is currently known about how vari...

    Authors: E. Dolan, A. Dumas, K. M. Keane, G. Bestetti, L. H. M. Freitas, B. Gualano, W. Kohrt, G. A. Kelley, R. M. R. Pereira, C. Sale and P. Swinton

    Citation: Systematic Reviews 2020 9:291

    Content type: Protocol

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  32. Economic evaluations help decision-makers faced with tough decisions on how to allocate resources. Systematic reviews of economic evaluations are useful as they allow readers to assess whether interventions ha...

    Authors: Gemma E. Shields and Jamie Elvidge

    Citation: Systematic Reviews 2020 9:289

    Content type: Commentary

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  33. The disease burden caused by type 2 diabetes mellitus is a prime public health concern. The prevalence and rate of deaths from diabetes mellitus in low- and middle-income countries (LMICs) are higher than the ...

    Authors: Anupam Sarker, Rina Das, Saraban Ether and K. M. Saif-Ur-Rahman

    Citation: Systematic Reviews 2020 9:288

    Content type: Protocol

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  34. Critically ill patients receiving invasive ventilation are at risk of sputum retention. Mechanical insufflation-exsufflation (MI-E) is a technique used to mobilise sputum and optimise airway clearance. Recentl...

    Authors: Ema Swingwood, Willemke Stilma, Lyvonne Tume, Fiona Cramp, Frederique Paulus, Marcus Schultz, Wilma Scholte op Reimer and Louise Rose

    Citation: Systematic Reviews 2020 9:287

    Content type: Protocol

    Published on:

  35. Although mindfulness-based interventions (MBIs) are becoming increasingly popular, the application of MBIs with children and adolescents is still in its infancy. Mapping the existing literature is necessary to...

    Authors: Marie-France Perrier, Nalia Gurgel-Juarez, Heather Leslie Flowers, Anna McCormick and Sarah J. Short

    Citation: Systematic Reviews 2020 9:286

    Content type: Protocol

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  36. FMS-like tyrosine kinase 3 (FLT3) is the most frequent mutation in AML. With two FLT3 inhibitors recently approved by the FDA (midostaurin and gilteritinib), there is a need to evaluate these targeted agents.

    Authors: S. Majothi, D. Adams, J. Loke, S. P. Stevens, K. Wheatley and J. S. Wilson

    Citation: Systematic Reviews 2020 9:285

    Content type: Research

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  37. Loneliness is a highly prevalent, harmful, and aversive experience which is fundamentally subjective: social isolation alone cannot account for loneliness, and people can experience loneliness even with ample ...

    Authors: Phoebe E. McKenna-Plumley, Jenny M. Groarke, Rhiannon N. Turner and Keming Yang

    Citation: Systematic Reviews 2020 9:284

    Content type: Protocol

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  38. Young people’s use of pornography and participation in sexting are commonly viewed as harmful behaviours. This paper reports findings from a ‘review of reviews’, which aimed to systematically identify and synt...

    Authors: Gary Raine, Claire Khouja, Rachel Scott, Kath Wright and Amanda J. Sowden

    Citation: Systematic Reviews 2020 9:283

    Content type: Research

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  39. Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its...

    Authors: Joseph J. Matthews, Eimear Dolan, Paul A. Swinton, Livia Santos, Guilherme G. Artioli, Mark D. Turner, Kirsty J. Elliott-Sale and Craig Sale

    Citation: Systematic Reviews 2020 9:282

    Content type: Protocol

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  40. Professionalism is a core competency of medical residents in residency programs. Unprofessional behavior has a negative influence on patient safety, quality of care, and interpersonal relationships. The object...

    Authors: Saeideh Ghaffarifar, Azam Asghari-Khatooni, Amirhossein Akbarzadeh, Ahmad Pourabbas, Mehran Seif Farshad, Rasoul Masoomi and Fariborz Akbarzadeh

    Citation: Systematic Reviews 2020 9:281

    Content type: Protocol

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  41. People aged ≥ 65 years comprise around 1 in 5 emergency department (ED) presentations. Many of these presentations occur due to complications associated with chronic diseases and frailty. This review aims to p...

    Authors: Ya-Ling Huang, Megan McGonagle, Rebecca Shaw, Julie Eastham, Nemat Alsaba and Julia Crilly

    Citation: Systematic Reviews 2020 9:280

    Content type: Protocol

    Published on:

  42. Liver resection (LR) in patients with liver metastasis from colorectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns r...

    Authors: Mihai-Calin Pavel, Raquel Casanova, Laia Estalella, Robert Memba, Erik Llàcer-Millán, Mar Achalandabaso, Elisabet Julià, Justin Geoghegan and Rosa Jorba

    Citation: Systematic Reviews 2020 9:279

    Content type: Protocol

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  43. Sub-Saharan Africa (SSA) homes most of the people living with HIV/AIDS in the world. Adolescents/young people are a vulnerable population and at high risk of HIV infection. Identifying and bridging the researc...

    Authors: Patience Adzordor, Clement Avoka, Vitalis Bawontuo, Silas Agbesi and Desmond Kuupiel

    Citation: Systematic Reviews 2020 9:278

    Content type: Protocol

    Published on:

  44. The challenge of implementing evidence-based innovations within practice settings is a significant public health issue that the field of implementation research (IR) is focused on addressing. Significant amoun...

    Authors: Bryan R. Garner, Sheila V. Patel and M. Alexis Kirk

    Citation: Systematic Reviews 2020 9:277

    Content type: Protocol

    Published on:

  45. Colorectal cancer (CRC) is a major cause of cancer deaths worldwide. Accumulating evidence suggests a potentially important role of colorectal infection with Fusobacterium nucleatum (F. nucleatum) in colorectal c...

    Authors: Amal Idrissi Janati, Igor Karp, Claudie Laprise, Hisham Sabri and Elham Emami

    Citation: Systematic Reviews 2020 9:276

    Content type: Research

    Published on:

  46. Health information technology (HIT) is known to reduce prescribing errors but may also cause new types of technology-generated errors (TGE) related to data entry, duplicate prescribing, and prescriber alert fa...

    Authors: Joan Devin, Brian J. Cleary and Shane Cullinan

    Citation: Systematic Reviews 2020 9:275

    Content type: Research

    Published on:

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