Treatment | Median risk ratio versus placebo–PASI 75 (95% CrI) | ||||
---|---|---|---|---|---|
All licensed doses | No previous biologic use (< 25%) | PASI score ≤ 25 | Weight ≤ 90 kg | ≥ 90% white patients | |
Adalimumab 40 mg | 12.74 (11.00–14.49) | 12.48 (10.91-14.13) | 13.09 (11.72-14.57) | 12.87 (10.29-15.39) | 13.18 (11.21-15.15) |
Brodalumab 210 mg | 16.76 (15.12–18.53) | 16.45 (14.66–18.31) | 16.62 (15.20–18.18) | 16.73 (14.97–18.58) | 16.56 (15.02–18.24) |
Certolizumab 200 mg | 12.07 (9.62–14.54) | 13.93 (8.63–18.20) | 12.08 (10.30–13.94) | 11.71 (9.11–14.27) | 12.13 (10.02–14.26) |
Certolizumab 400 mg | 13.47 (11.09–15.80) | 15.73 (10.81–19.08) | 13.42 (11.65–15.23) | 13.04 (10.53–15.46) | 13.48 (11.42–15.52) |
Etanercept 25 mg | 7.61 (5.52–10.11) | – | 7.64 (6.20–9.20) | – | 7.89 (5.60–10.51) |
Etanercept 50 mg once–weekly | 10.67 (7.96–13.53) | 5.08 (3.50–7.07) | 6.16 (4.69–7.90) | 5.57 (3.91–7.65) | 7.07 (4.57–10.20) |
Etanercept 50 mg twice per week | 9.90 (8.68–11.21) | 9.46 (8.27–10.77) | 10.40 (9.47–11.40) | 9.85 (8.27–11.55) | 10.33 (9.01–11.75) |
Guselkumab 100 mg | 17.06 (15.30–18.91) | 16.68 (15.07–18.42) | 16.83 (15.32–18.46) | – | 15.30 (10.89–18.39) |
Infliximab 5 mg | 16.22 (14.37–18.15) | 16.88 (14.66–19.03) | 15.46 (13.85–17.17) | 14.19 (11.76–16.56) | 15.38 (13.41–17.36) |
Ixekizumab 80 mg | 17.64 (16.06–19.36) | 17.42 (15.89–19.09) | 17.79 (16.30–19.41) | 17.16 (14.67–19.33) | 17.75 (16.23–19.41) |
Risankizumab 150 mg | 16.46 (14.37–18.47) | – | – | – | – |
Secukinumab 300 mg | 16.45 (14.79–18.23) | 16.03 (14.41–17.73) | 16.43 (15.03–17.96) | 16.12 (14.55–17.82) | 18.67 (16.22–20.81) |
Ustekinumab 45 mg | 13.59 (11.79–15.44) | 12.20 (10.32–14.14) | 13.46 (12.17–14.84) | 13.04 (10.35–15.63) | 13.68 (11.95–15.48) |
Ustekinumab 90 mg | 14.67 (12.85–16.54) | 13.36 (11.29–15.38) | 14.51 (13.20–15.95) | 14.36 (10.18–17.57) | 14.64 (13.00–16.37) |
Ustekinumab (45 mg or 90 mg) | 12.85 (11.07–14.67) | 12.96 (11.05–14.94) | 13.19 (11.79–14.66) | 13.11 (10.99–15.20) | 13.14 (11.35–14.95) |
Tildrakizumab 100 mg | 14.86 (12.49–17.02) | 15.03 (13.18–16.91) | 15.82 (14.25–17.50) | 15.28 (13.31–17.21) | 16.21 (14.20–18.16) |
Apremilast | 5.80 (4.20–7.61) | 3.77 (2.48–5.59) | 5.17 (4.01–6.61) | 3.91 (2.60–5.79) | 5.46 (4.12–7.10) |
Dimethyl Fumarate | 2.97 (1.44–5.73) | 2.97 (1.77–4.88) | 2.97 (1.71–5.01) | – | 2.96 (1.71–4.98) |
Fumaderm | 3.31 (1.62–6.26) | 3.32 (1.97–5.41) | 3.31 (1.94–5.53) | – | 3.30 (1.92–5.48) |
Methotrexate | 6.15 (4.07–8.65) | 10.47 (6.73–14.41) | 6.50 (4.69–8.60) | 5.49 (3.56–8.12) | 6.30 (4.37–8.61) |
Acitretin | 4.024 (1.55–8.39) | – | 4.07 (1.59–8.29) | – | 4.29 (1.74–8.43) |
Cyclosporin 1.5 mg | 8.10 (2.41–16.91) | – | – | – | 2.14 (0.38–10.53) |
Cyclosporin 2.5 mg | 7.10 (2.02–16.34) | – | – | – | 6.76 (2.07–16.03) |