Fig. 1From: Equivalence and switching between biosimilars and reference molecules in rheumatoid arthritis: protocol for a systematic review and meta-analysisBoundaries of equivalence (dashed lines) for a two-sided 95% confidence interval of the treatment difference. A Equivalence margins for ACR20 (primary outcome). B Equivalence margins for HAQ-DI (co-primary outcome). If the summary 95% CI lies within the gray regions, the null hypothesis will be rejected, and equivalence will be claimedBack to article page