Table 1 Selection of exclusion criteria in screening
Selection phase | Exclusion criterion | Remark |
|---|---|---|
Title—abstract | Not a primary study | - |
Not an in vivo vertebrate (non-human) healthy animal study | - | |
Not the aim to study effects of isoflurane (e.g., co-morbidities, co-interventions) | Isoflurane (or any other of the descriptors used for “isoflurane” in the search strategy) are not in the title (see Supplemental materials 2, 3 and 4) | |
Obviously very young animals exposed to isoflurane | At this stage, we are unsure whether EPPI reviewer will be able to make a distinction between isoflurane exposure of obviously young animals (which should be excluded) versus maternal exposure and outcomes measured in offspring (which should be included). We are therefore not yet sure if this criterion will be part of the final title abstract screening | |
Only studies that reported treatment with 1 vol% isoflurane or higher | - | |
No abstract available | - | |
Full text | Sexually immature animals exposed to isoflurane | Above described criterion is redefined if EPPI reviewer will not be able to interpret sexual maturity per species |
Combined use of multiple anaesthetics | - | |
Lowest maintenance dose described in paper higher than 1% | Exposures too high to be relevant in an occupational setting will not be included (Menon et al., 2021) |