Skip to main content

Table 5 GRADE certainty of SRs and meta-analyses by main outcomes and measurements

From: Effects and mechanisms of Tai Chi on mild cognitive impairment and early-stage dementia: a scoping review

Outcome

Estimate of effect [95% CI]

I2

No. of participants (studies)

Total score

Reason1

GRADE certainty

Global cognition

 Tai Chi vs (health talk, muscle-stretching and toning exercise, usual lifestyle, usual care, health education)

SMD 0.4 [− 0.13, 0.93]

88%

574 (5)

 − 4

a, h, d

Very low

 Tai Chi vs (stretching and toning exercise, related health education, usual daily activities)

MD 1.98 (1.32, 2.65)

74%

780 (8)

 − 1

a

Moderate

 Tai Chi vs (playing cards or singing, stretching and toning exercise, Escitalopram plus health education, education)

SMD 0.40 (0.08, 0.73)

79%

858 (5)

 − 3

a, h

Very low

 Tai Chi vs stretching and toning exercise

SMD 0.38 (0.22, 0.55)

0%

590 (2)

 − 1

a

Moderate

 Tai Chi vs (cognitive behaviour therapy, usual care, stretching, health education, recreational activities)

MD 0.29 (− 0.16, 0.74)

0%

785 (5)

 − 1

d

Moderate

 Tai Chi vs stretching and toning exercise

SMD 0.44 (0.24, 0.64)

27%

590 (2)

 − 1

a

Moderate

Memory

 Tai Chi vs (health talk, muscle-stretching and toning exercise, health education)

SMD 0.40 (− 0.10, 0.90)

75%

379 (3)

 − 3

a, b, d

Very low

 Tai Chi vs (educational class, unaltered lifestyle, memory training)

SMD 0.77 (0.45, 1.09)

23.8%

226 (4)

 − 2

f

Low

 Tai Chi vs (stretching, daily activity, health education)

MD 0.37 (0.13, 0.61)

7%

726 (4)

0

 

High

Attention

 Tai Chi vs (maintain usual daily physical activities, stretching and toning exercise)

SMD 0.57 (− 0.25, 1.40)

74%

287 (2)

 − 2

a, d

Low

 Tai Chi vs (maintain usual daily physical activities, stretching and toning exercise)

SMD 0.03 (− 0.22, 0.27)

0%

287 (2)

 − 2

a, d

Low

Executive function

 Tai Chi vs (muscle-stretching and toning exercise, Health education)

SMD 0.10 (− 0.16, 0.35)

13%

327 (2)

 − 2

a, d

Low

 Tai Chi vs (maintain usual daily physical activities, stretching and toning exercise)

SMD 0.79 (− 1.08, 0.51)

0%

209 (3)

 − 2

a, d

Low

 Tai Chi vs (stretching, daily activity, health education)

MD 0.03 (− 0.16, 0.22)

0%

726 (4)

 − 1

d

Moderate

Verbal fluency

 Tai Chi vs stretching

MD 0.47 (− 0.76, 1.70)

0%

231 (2)

 − 1

d

Moderate

Visual span

 Tai Chi vs (stretching, health education, daily activity)

SMD 0.57 (0.23, 0.91)

75%

726 (4)

 − 1

b

Moderate

Depressive symptoms

 Tai Chi vs (stretching, cognitive behaviour therapy, usual care)

SMD 0 (− 0.14, 0.15)

0%

730 (4)

 − 1

d

Moderate

  1. 1Reasons: risk of bias (a − 1: serious, f − 2: very serious); inconsistency (b serious, h very serious); indirectness (c serious, i very serious); imprecision (d serious, j very serious); publication bias (e serious, k very serious)
  2. a, some concerns (one or two RoB categories > 75%); b heterogeneity I2 ≥ 75% or NI and all RCTs favour one direction, d MA sample size: ≥ 200 and 95%CI overlaps zero, f high risk of bias (all three RoB categories ≤ 75%), h heterogeneity I2 ≥ 75% or NI and mixed direction of results ± low overlap of CI (confirm with a visual inspection of Forest plot)