Minimal clinically important change of knee flexion in people with knee osteoarthritis after non-surgical interventions using a meta-analytical approach

Table 1 Eligibility criteria of included studies

Inclusion criteria	Exclusion criteria
Randomised clinical trials including placebo-controlled trials, cluster-randomised trials and cross-over trials	Does not contain original data (e.g. systematic reviews, literature reviews and editorial commentaries)
Adults (aged 18 years or older) who have been diagnosed with knee osteoarthritis using any standard diagnostic criteria (clinically and/or radiographically)	Conference abstracts, research protocols and materials not published as a full peer-reviewed paper
Any nonsurgical intervention included (e.g. exercises, kinesio taping, massage therapy, herbal treatment and pharmacological)	Participants with knee osteoarthritis concurrently with participants with osteoarthritis in other joints unless data are reported separately
Treatment duration of 3 months or less	Participants with knee osteoarthritis concurrently with participants with other disorders such as rheumatoid arthritis, neck pain and back pain, unless data are reported separately
Estimate of change of knee flexion and patient-reported outcome measures^a immediately after the interventions
Outcomes reported on pre- and post-intervention

^aThe patient-reported outcome measures are selected that have known MCIC and MCID of outcome tools, namely ICOAP, intermittent and constant osteoarthritis pain
KOOS knee injury and osteoarthritis outcome score, LEFS Lower Extremity Functional Scale, NPRS Numeric Pain Rating Scale, PROMIS Patient-Reported Outcome Measurement Information System, SF-36 36-Item Short-Form Health Survey, VAS Visual Analog Scale, WOMAC, Western Ontario and McMaster Universities Arthritis Index

ISSN: 2046-4053