Sr.no | Authors with year of publication | Mean age (months) | Not on hydroxyurea therapy | On hydroxyurea therapy | Hydroxyurea dose (mg/kg/day) | ||||
---|---|---|---|---|---|---|---|---|---|
N | Incidence of stroke /100-person yeara | Mean HbF level | N | Incidence of stroke /100-person year | Mean HbF level | ||||
1 | Hankins JS et al. 2008 | 132 | 25 | 2.54 | 4 | 18 | 1.9 | 18.2 | 30 |
2 | Wang WC et al. 2001 | 15 | 16 | 10 | 21.8 | 14 | 7.14 | 20.2 | 20 |
3 | Nottage KA et al. 2016 | 113 | 50 | 4.04 | 5 | 30 | 1.1 | 14 | 20 |
4 | Wang WC et al. 2021 | 149 | 19 | 3.82 | 8.2 | 9 | 11.10 | 23.1 | 23.8 |