No | References | language | Animal models | Intervention (treatment group) | Intervention (control group) | License of acupuncturists | Specimen | Oxidative stress indicators | Behavioral tests | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sources | Species | Sex, number | Age (months), weight | Modelling method | Degree and duration of ischemia | Type | Acupoints | Duration (days)/ frequency (daily) | Electroacupuncture parameters | ||||||||
1 | Li et al., 2021 [26] | Chinese | Laboratory Animal Center, Guangzhou University of TCM | Wistar rat | Male 54 | 4–5 mo, 300-320 g | BCCA | NR | MA | GV20, ST36 | 14 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | ROS, MDA, SOD | ①② |
2 | Wang et al., 2015 [34] | English | Vital River Laboratory Animal Technology Company | Wistar rat | Male 30 | NR, 200-220 g | BCCA | NR | MA | GV20, ST36 | 14 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | ROS | ①②③ |
3 | Liu et al., 2004 [44] | Chinese | The 4th Institute of the Chinese People's Liberation Army Academy of Military Medical Sciences | Wistar rat | Female/Male 29 | 10 mo, 340 ± 40 g | TM | NR | MA | RN17, RN12, RN6, SP10, ST36 | 21 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | MDA, SOD, GSH-Px, NO, NOS | ①②④⑤ |
4 | Qiu et al., 2022 [32] | Chinese | Hunan Slack Jingda Experimental Animal Company | Sprague Dawley rat | Male 20 | NR, 220-250 g | BCCA | NR | EA | GV20, GV14, BL23 | 28 d, 1 time | Sparse wave, 10-50HZ | Non-intervention group | NR | Hippocampus | ROS | ①④⑤ |
5 | Zhu et al., 2018 [24] | English | Vital River Laboratory Animal Technology Company | Wistar rat | Male 30 | NR, 200-220 g | BCCA | NR | MA | GV20, ST36 | 28 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | ROS | ①③④⑥ |
6 | Li et al., 2016 [30] | English | Vital River Laboratory Animal Technology Company | Wistar rat | Male 42 | NR, 270-320 g | BCCA | NR | MA | GV20, ST36 | 14 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | ROS | ①② |
7 | Du et al., 2018 [33] | English | Vital River Laboratory Animal Technology Company | Wistar rat | Male 30 | 2.5 mo, NR | BCCA | NR | MA | GV20, ST36 | 14 d, 1 time | - | Non-intervention group; sham-acupuncture group | Y | Hippocampus | ROS, SOD | ①②⑥ |
8 | Yang et al., 2018 [25] | English | Vital River Laboratory Animal Technology Company | Wistar rat | Male 18 | 2 mo, 280-320 g | BCCA | NR | MA | GV20, ST36 | 14 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | ROS, SOD | ①②③⑤ |
9 | Hu et al., 2022 [31] | Chinese | Hunan Slack Jingda Experimental Animal Company | Sprague Dawley rat | Male 18 | NR, 220-250 g | BICA | NR | EA | GV20, ST36 | 14 d, 1 time | Sparse wave, 1-2 Hz, 1.5 mA | Non-intervention group | NR | Hippocampus; serum | SOD, GSH-Px, CAT, MDA, ROS | ①②④ |
10 | Cheng et al., 2022 [35] | Chinese | Liaoning Changsheng Biotechnology Company., LTD | Sprague Dawley rat | Male 30 | 3 mo, 180 ± 20 g | BCCA | NR | EA | ST36, SP6 | 5 d, 1 time | NR | Non-intervention group; sham-acupuncture group | NR | Hippocampus | ROS, SOD, MDA | ①④ |
11 | Song et al., 2018 [42] | Chinese | Shanghai Slack Laboratory Animal Company | Sprague Dawley rat | Female 20 | 11–15 mo, 370 g | BICOCA | NR | EA | RN4, SP6 | 20 d, 1 time | Continuous wave, 2 Hz | Non-intervention group | NR | Hippocampus | SOD, MDA | ① |
12 | Li et al., 2017 [36] | Chinese | Laboratory Animal Center, Heilongjiang University of TCM | Sprague Dawley rat | Male 20 | 3 mo, 280-300 g | 4-VO | NR | MA | GV20, GV24, GV14, ST36 | 16 d, 1 time | - | Non-intervention group | NR | Hippocampus | SOD, MDA | ①④ |
13 | Zhang et al., 2014 [37] | English | NR | Wistar rat | Male 30 | NR, 300-320 g | TM | NR | MA | CV17, CV12, CV6, ST36, SP10 | 21 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Brain tissues | SOD, MDA | ①②④ |
14 | Liu et al., 2013 [38] | English | The 4th Institute of the Chinese People's Liberation Army Academy of Military Medical Sciences | Wistar rat | Male 48 | NR, 340 ± 40 g | TM | NR | MA | CV17, CV12, CV6, ST36, SP10 | 21 d, 1 time | - | Non-intervention group; sham-acupuncture group | Y | Hippocampus | Ref-1 | ③⑤⑦ |
15 | Ji et al., 2011 [45] | Chinese | Laboratory Animal Center, The Fourth Military Medical University of the People's Liberation Army | Sprague Dawley rat | Female/Male 20 | NR, 220-260 g | 4-VO | 5 min for three times, each with an interval of 1 h | MA | GV20, RN17, RN6, BL17, SP6 | 30 d, 1 time | - | Non-intervention group; sham-acupuncture group | NR | Hippocampus | SOD, MDA | ①④ |
16 | Liu et al., 2010 [39] | Chinese | NR | Wistar rat | Male 90 | 8 mo, 320-360 g | TM | NR | MA | RN17, RN12, RN6, SP10, ST36 | 21 d, 1 time | - | Non-intervention group; sham-acupuncture | NR | Hippocampus | GSH, GSSG, Ref-1 | ①③⑤⑦ |
17 | Yan et al., 2008 [48] | Chinese | Laboratory Animal Center, Guangzhou University of TCM | Sprague Dawley rat | Female/Male 25 | NR, 180-220 g | 4-VO | 5 min for three times, each with an interval of 1 h | EA | GV20, BL17, BL20, BL23 | 15 d, 1 time | Continuous wave, 150 Hz | Non-intervention group; drug group | NR | Brain tissues | NO | ①④ |
18 | Meng et al., 2007 [43] | Chinese | Laboratory Animal Center, Hubei University of TCM | Sprague Dawley rat | Male 67 | NR, 200-250 g | MCA | 1.5 h | EA | GV20, BL23, Hou San Li (posterolateral knee joint, about 5 mm below the small head of fibula) | 15d, 1 time | Continuous wave, 2 Hz | Non-intervention group | NR | Hippocampus | NO, NOS | ①④⑤ |
19 | Chen et al., 2006 [47] | Chinese | Laboratory Animal Center, Guangzhou University of TCM | Sprague Dawley rat | 1/1 30 | NR, 180-200 g | 4-VO | 5 min for three times, each with an interval of 1 h | EA | GV20, BL23, BL20 | 15 d, 1 time | Sparse wave,16 Hz | Non-intervention group; drug group | NR | Brain tissues | NO, NOS | ①④ |
20 | Wang et al., 2006 [40] | Chinese | Shanghai Laboratory Animal Center, Chinese Academy of Sciences | Sprague Dawley rat | Male 26 | NR, 180-200 g | BICA | 20 min for two times, each with an interval of 10 min | EA | GV20, 1 point (0.2 cuns far from GV14) | 30 d, once 2 days | Sparse wave,15 Hz | Non-intervention group | NR | Brain tissues | NO, SOD | ①④ |
21 | Wang et al., 2002 [48] | Chinese | Laboratory Animal Center, Guangzhou University of TCM | Sprague Dawley rat | Female/Male 40 | 2–3 mo, 200-250 g | 4-VO | 5 min for three times, each with an interval of 1 h | EA | GV20, GV14 | 30 d, 1 time | Continuous wave, 150 Hz, 0.2 mA | Non-intervention group; drug group | NR | Brain tissues | NO, NOS, MDA, SOD, GSH-PX | ①④ |
22 | Lai et al., 2000 [41] | Chinese | Laboratory Animal Center, Guangzhou University of TCM | Sprague Dawley rat | Male 30 | NR, 200-250 g | 4-VO | 5 min for three times, each with an interval of 1 h | EA | GV20, GV14 | 10 d, 1 time | Continuous wave, 150 Hz | Non-intervention group; drug group | NR | Brain tissues | MDA, SOD |